SEC20_HUMAN » Vesicle transport protein SEC20

SEC20_HUMAN » Vesicle transport protein SEC20
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SEC20_HUMAN » Vesicle transport protein SEC20 » BCL2/adenovirus E1B 19 kDa protein-interacting protein 1;Transformation-related gene 8 protein;TRG-8;
Hydrophobic Thickness 30.8 ± 2.6 Å
Tilt Angle 30 ± 12°
ΔGtransfer -27.5 kcal/mol
ΔGfold -20.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 197-221 (196-222)
Pathways

SNARE interactions in vesicular transport (KEGG)

PDB none
OPM none
Complexes none
Interactions

A4, Complex: SEC20:A4, PubMed

B2CL1, Complex: B2CL1:SEC20, PubMed

BCL2, Complex: SEC20:BCL2, PubMed

STX18, Complex: STX18:SEC20, PubMed

Domains

AA: 133-224, Sec20

UniProt annotation for SEC20_HUMAN » Vesicle transport protein SEC20
FUNCTION: SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death. May be involved in mitochondrial autophagy.

SUBUNIT: Component of a SNARE complex consisting of STX18, USE1L, BNIP1/SEC20L and SEC22B. Interacts directly with STX18, RINT1/TIP20L and NAPA. Interacts with ZW10 through RINT1. Interacts with BCL2 and adenovirus E1B 19 kDa protein.

TISSUE SPECIFICITY: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.

MISCELLANEOUS: Silencing of BNIP1 disrupts ER morphology.

UniProt features for SEC20_HUMAN » Vesicle transport protein SEC20
CHAIN 1 228 Vesicle transport protein SEC20.
COILED 37 90 Potential.
Amino Acid Sequence for SEC20_HUMAN » Vesicle transport protein SEC20
MAAPQDVHVR ICNQEIVKFD LEVKALIQDI RDCSGPLSAL TELNTKVKEK FQQLRHRIQD LEQLAKEQDK ESEKQLLLQE VENHKKQMLS NQASWRKANL TCKIAIDNLE KAELLQGGDL LRQRKTTKES LAQTSSTITE SLMGISRMMA QQVQQSEEAM QSLVTSSRTI LDANEEFKSM SGTIQLGRKL ITKYNRRELT DKLLIFLALA LFLATVLYIV KKRLFPFL