SE6L2_HUMAN » Seizure 6-like protein 2

SE6L2_HUMAN » Seizure 6-like protein 2
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SE6L2_HUMAN » Seizure 6-like protein 2 »
Hydrophobic Thickness 31.2 ± 3.8 Å
Tilt Angle 17 ± 1°
ΔGtransfer -21.6 kcal/mol
ΔGfold -13.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 845-866 (845-870)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 290-345, PDBID: 1C1Z, Subunit A, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 464-523, PDBID: 1C1Z, Subunit A, Seq Identity:30%, Sushi repeat (SCR repeat)

AA: 527-633, PDBID: 2QQK, Subunit A, Seq Identity:33%, CUB domain

AA: 644-699, PDBID: 2YRA, Subunit A, Seq Identity:61%, Sushi repeat (SCR repeat)

AA: 705-764, PDBID: 1G40, Subunit B, Seq Identity:37%, Sushi repeat (SCR repeat)

AA: 771-828, PDBID: 2EHF, Subunit A, Seq Identity:37%, Sushi repeat (SCR repeat)

UniProt annotation for SE6L2_HUMAN » Seizure 6-like protein 2
FUNCTION: May contribute to specialized endoplasmic reticulum functions in neurons.

INDUCTION: Increased expression in the majority of primary lung cancers and lung-cell lines tested.

MISCELLANEOUS: May serve as a prognostic marker for lung cancers.

UniProt features for SE6L2_HUMAN » Seizure 6-like protein 2
SIGNAL 1 27
CHAIN 28 910 Seizure 6-like protein 2.
DOMAIN 173 286 CUB 1.
DOMAIN 288 347 Sushi 1.
DOMAIN 349 459 CUB 2.
DOMAIN 462 525 Sushi 2.
DOMAIN 527 638 CUB 3.
DOMAIN 642 701 Sushi 3.
DOMAIN 703 766 Sushi 4.
DOMAIN 769 830 Sushi 5.
REGION 41 48 O-glycosylated at one site.
DISULFID 173 202 By similarity.
DISULFID 290 330 By similarity.
DISULFID 316 345 By similarity.
DISULFID 349 376 By similarity.
DISULFID 464 508 By similarity.
DISULFID 491 523 By similarity.
DISULFID 527 553 By similarity.
DISULFID 644 686 By similarity.
DISULFID 672 699 By similarity.
DISULFID 705 747 By similarity.
DISULFID 733 764 By similarity.
DISULFID 771 813 By similarity.
DISULFID 799 828 By similarity.
Amino Acid Sequence for SE6L2_HUMAN » Seizure 6-like protein 2
MGTPRAQHPP PPQLLFLILL SCPWIQGLPL KEEEILPEPG SETPTVASEA LAELLHGALL RRGPEMGYLP GSDPDPTLAT PPAGQTLAVP SLPRATEPGT GPLTTAVTPN GVRGAGPTAP ELLTPPPGTT APPPPSPASP GPPLGPEGGE EETTTTIITT TTVTTTVTSP VLCNNNISEG EGYVESPDLG SPVSRTLGLL DCTYSIHVYP GYGIEIQVQT LNLSQEEELL VLAGGGSPGL APRLLANSSM LGEGQVLRSP TNRLLLHFQS PRVPRGGGFR IHYQAYLLSC GFPPRPAHGD VSVTDLHPGG TATFHCDSGY QLQGEETLIC LNGTRPSWNG ETPSCMASCG GTIHNATLGR IVSPEPGGAV GPNLTCRWVI EAAEGRRLHL HFERVSLDED NDRLMVRSGG SPLSPVIYDS DMDDVPERGL ISDAQSLYVE LLSETPANPL LLSLRFEAFE EDRCFAPFLA HGNVTTTDPE YRPGALATFS CLPGYALEPP GPPNAIECVD PTEPHWNDTE PACKAMCGGE LSEPAGVVLS PDWPQSYSPG QDCVWGVHVQ EEKRILLQVE ILNVREGDML TLFDGDGPSA RVLAQLRGPQ PRRRLLSSGP DLTLQFQAPP GPPNPGLGQG FVLHFKEVPR NDTCPELPPP EWGWRTASHG DLIRGTVLTY QCEPGYELLG SDILTCQWDL SWSAAPPACQ KIMTCADPGE IANGHRTASD AGFPVGSHVQ YRCLPGYSLE GAAMLTCYSR DTGTPKWSDR VPKCALKYEP CLNPGVPENG YQTLYKHHYQ AGESLRFFCY EGFELIGEVT ITCVPGHPSQ WTSQPPLCKV TQTTDPSRQL EGGNLALAIL LPLGLVIVLG SGVYIYYTKL QGKSLFGFSG SHSYSPITVE SDFSNPLYEA GDTREYEVSI