SE6L1_HUMAN » Seizure 6-like protein

SE6L1_HUMAN » Seizure 6-like protein
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SE6L1_HUMAN » Seizure 6-like protein »
Hydrophobic Thickness 33.8 ± 2.4 Å
Tilt Angle 4 ± 11°
ΔGtransfer -24.5 kcal/mol
ΔGfold -18.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 957-979 (957-988)
Pathways none
PDB 2yra (745-802)
OPM none
Complexes none
Interactions none
Domains

AA: 393-448, PDBID: 1C1Z, Subunit A, Seq Identity:36%, Sushi repeat (SCR repeat)

AA: 452-559, PDBID: 2QQK, Subunit A, Seq Identity:29%, CUB domain

AA: 567-624, PDBID: 2YRA, Subunit A, Seq Identity:33%, Sushi repeat (SCR repeat)

AA: 628-736, PDBID: 1SFP, Subunit A, Seq Identity:35%, CUB domain

AA: 745-800, PDBID: 2YRA, Subunit A, Seq Identity:100%, Sushi repeat (SCR repeat)

AA: 806-865, PDBID: 1H03, Subunit P, Seq Identity:33%, Sushi repeat (SCR repeat)

AA: 873-930, PDBID: 2EHF, Subunit A, Seq Identity:40%, Sushi repeat (SCR repeat)

UniProt annotation for SE6L1_HUMAN » Seizure 6-like protein
FUNCTION: May contribute to specialized endoplasmic reticulum functions in neurons.

TISSUE SPECIFICITY: Widely expressed, including adult and fetal brains and lungs. Not expressed in all lung cancer cell lines.

UniProt features for SE6L1_HUMAN » Seizure 6-like protein
SIGNAL 1 28 Potential.
CHAIN 29 1024 Seizure 6-like protein.
DOMAIN 281 389 CUB 1.
DOMAIN 391 450 Sushi 1.
DOMAIN 452 562 CUB 2.
DOMAIN 565 626 Sushi 2.
DOMAIN 628 739 CUB 3.
DOMAIN 743 802 Sushi 3.
DOMAIN 804 867 Sushi 4.
DOMAIN 871 932 Sushi 5.
REGION 147 161 O-glycosylated at one site.
REGION 176 180 O-glycosylated at one site.
DISULFID 281 308 By similarity.
DISULFID 393 433 By similarity.
DISULFID 419 448 By similarity.
DISULFID 567 609 By similarity.
DISULFID 594 624 By similarity.
DISULFID 745 787 By similarity.
DISULFID 773 800 By similarity.
DISULFID 806 848 By similarity.
DISULFID 834 865 By similarity.
DISULFID 873 915 By similarity.
DISULFID 901 930 By similarity.
Amino Acid Sequence for SE6L1_HUMAN » Seizure 6-like protein
MPAARPPAAG LRGISLFLAL LLGSPAAALE RDALPEGDAS PLGPYLLPSG APERGSPGKE HPEERVVTAP PSSSQSAEVL GELVLDGTAP SAHHDIPALS PLLPEEARPK HALPPKKKLP SLKQVNSARK QLRPKATSAA TVQRAGSQPA SQGLDLLSSS TEKPGPPGDP DPIVASEEAS EVPLWLDRKE SAVPTTPAPL QISPFTSQPY VAHTLPQRPE PGEPGPDMAQ EAPQEDTSPM ALMDKGENEL TGSASEESQE TTTSTIITTT VITTEQAPAL CSVSFSNPEG YIDSSDYPLL PLNNFLECTY NVTVYTGYGV ELQVKSVNLS DGELLSIRGV DGPTLTVLAN QTLLVEGQVI RSPTNTISVY FRTFQDDGLG TFQLHYQAFM LSCNFPRRPD SGDVTVMDLH SGGVAHFHCH LGYELQGAKM LTCINASKPH WSSQEPICSA PCGGAVHNAT IGRVLSPSYP ENTNGSQFCI WTIEAPEGQK LHLHFERLLL HDKDRMTVHS GQTNKSALLY DSLQTESVPF EGLLSEGNTI RIEFTSDQAR AASTFNIRFE AFEKGHCYEP YIQNGNFTTS DPTYNIGTIV EFTCDPGHSL EQGPAIIECI NVRDPYWNDT EPLCRAMCGG ELSAVAGVVL SPNWPEPYVE GEDCIWKIHV GEEKRIFLDI QFLNLSNSDI LTIYDGDEVM PHILGQYLGN SGPQKLYSST PDLTIQFHSD PAGLIFGKGQ GFIMNYIEVS RNDSCSDLPE IQNGWKTTSH TELVRGARIT YQCDPGYDIV GSDTLTCQWD LSWSSDPPFC EKIMYCTDPG EVDHSTRLIS DPVLLVGTTI QYTCNPGFVL EGSSLLTCYS RETGTPIWTS RLPHCVSEES LACDNPGLPE NGYQILYKRL YLPGESLTFM CYEGFELMGE VTIRCILGQP SHWNGPLPVC KVNQDSFEHA LEVAEAAAET SLEGGNMALA IFIPVLIISL LLGGAYIYIT RCRYYSNLRL PLMYSHPYSQ ITVETEFDNP IYETGETREY EVSI