SE1L2_HUMAN » Protein sel-1 homolog 2

SE1L2_HUMAN » Protein sel-1 homolog 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SE1L2_HUMAN » Protein sel-1 homolog 2 » Suppressor of lin-12-like protein 2;Sel-1L2;
Hydrophobic Thickness 30.2 ± 2.7 Å
Tilt Angle 11 ± 4°
ΔGtransfer -17.5 kcal/mol
ΔGfold -6.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 665-685 (665-686)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 143-178, PDBID: 1KLX, Subunit A, Seq Identity:25%, Sel1 repeat

AA: 179-214, PDBID: 3RJV, Subunit A, Seq Identity:39%, Sel1 repeat

AA: 216-247, PDBID: 1OUV, Subunit A, Seq Identity:45%, Sel1 repeat

AA: 300-333, PDBID: 1OUV, Subunit A, Seq Identity:45%, Sel1 repeat

AA: 334-370, PDBID: 1OUV, Subunit A, Seq Identity:32%, Sel1 repeat

AA: 371-406, PDBID: 1OUV, Subunit A, Seq Identity:46%, Sel1 repeat

AA: 407-442, PDBID: 3RJV, Subunit A, Seq Identity:37%, Sel1 repeat

AA: 443-478, PDBID: 3RJV, Subunit A, Seq Identity:42%, Sel1 repeat

AA: 551-586, PDBID: 1KLX, Subunit A, Seq Identity:34%, Sel1 repeat

AA: 588-620, PDBID: 1OUV, Subunit A, Seq Identity:39%, Sel1 repeat

UniProt features for SE1L2_HUMAN » Protein sel-1 homolog 2
SIGNAL 1 23 Potential.
CHAIN 24 688 Protein sel-1 homolog 2.
REPEAT 107 142 Sel1-like 1.
REPEAT 143 178 Sel1-like 2.
REPEAT 179 214 Sel1-like 3.
REPEAT 215 250 Sel1-like 4.
REPEAT 297 333 Sel1-like 5.
REPEAT 334 370 Sel1-like 6.
REPEAT 371 406 Sel1-like 7.
REPEAT 407 442 Sel1-like 8.
REPEAT 443 478 Sel1-like 9.
REPEAT 551 586 Sel1-like 10.
REPEAT 588 623 Sel1-like 11.
CROSSLNK 101 101 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin).
Amino Acid Sequence for SE1L2_HUMAN » Protein sel-1 homolog 2
MKPLSLLIEI LIILGVTIKT IKAEEHNKRQ KERNVTTQVS VNEIKQYLSH ILEQRTSSNV INKRENLLEK KKNQRKIRIK GIQNKDILKR NKNHLQKQAE KNFTDEGDQL FKMGIKVLQQ SKSQKQKEEA YLLFAKAADM GNLKAMEKMA DALLFGNFGV QNITAAIQLY ESLAKEGSCK AQNALGFLSS YGIGMEYDQA KALIYYTFGS AGGNMMSQMI LGYRYLSGIN VLQNCEVALS YYKKVADYIA DTFEKSEGVP VEKVRLTERP ENLSSNSEIL DWDIYQYYKF LAERGDVQIQ VSLGQLHLIG RKGLDQDYYK ALHYFLKAAK AGSANAMAFI GKMYLEGNAA VPQNNATAFK YFSMAASKGN AIGLHGLGLL YFHGKGVPLN YAEALKYFQK AAEKGWPDAQ FQLGFMYYSG SGIWKDYKLA FKYFYLASQS GQPLAIYYLA KMYATGTGVV RSCRTAVELY KGVCELGHWA EKFLTAYFAY KDGDIDSSLV QYALLAEMGY EVAQSNSAFI LESKKANILE KEKMYPMALL LWNRAAIQGN AFARVKIGDY HYYGYGTKKD YQTAATHYSI AANKYHNAQA MFNLAYMYEH GLGITKDIHL ARRLYDMAAQ TSPDAHIPVL FAVMKLETTH LLRDILFFNF TTRWNWLKLD NTIGPHWDLF VIGLIVPGLI LLLRNHHG