SE1L1_HUMAN » Protein sel-1 homolog 1

SE1L1_HUMAN » Protein sel-1 homolog 1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SE1L1_HUMAN » Protein sel-1 homolog 1 » Suppressor of lin-12-like protein 1;Sel-1L;
Hydrophobic Thickness 29.0 ± 3.3 Å
Tilt Angle 1 ± 12°
ΔGtransfer -18.3 kcal/mol
ΔGfold -15.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 743-762 (741-765)
Pathways

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

AUP1, Complex: UB2J1:SE1L1:FAF2:AUP1:OS9, PubMed

BASI, Complex: SE1L1:BASI, PubMed

EDEM1, Complex: SE1L1:EDEM1, PubMed

EGFR, Complex: SE1L1:EGFR

ERN1, Complex: ERN1:SE1L1, PubMed

IGHM, Complex: IGHM:SE1L1, PubMed

ITA5, Complex: SE1L1:ITA5

ITB1, Complex: SE1L1:ITB1

ITB4, Complex: SE1L1:ITB4

RPN1, Complex: RPN1:SE1L1, PubMed

SARAF, Complex: SARAF:SE1L1, PubMed

SELS, Complex: DERL1:TERA:SELS:SE1L1:SYVN1:DERL2

SYJ2B, Complex: SYJ2B:SE1L1, PubMed

TNR1A, Complex: SE1L1:TNR1A, PubMed

UB2J1, Complex: UB2J1:SE1L1, PubMed

UBP19, Complex: SE1L1:UBP19

Domains

AA: 127-168, PDBID: 1L6J, Subunit A, Seq Identity:69%, Fibronectin type II domain

AA: 183-218, PDBID: 1OUV, Subunit A, Seq Identity:30%, Sel1 repeat

AA: 219-254, PDBID: 1KLX, Subunit A, Seq Identity:31%, Sel1 repeat

AA: 291-324, PDBID: 1OUV, Subunit A, Seq Identity:37%, Sel1 repeat

AA: 373-409, PDBID: 1OUV, Subunit A, Seq Identity:34%, Sel1 repeat

AA: 410-446, PDBID: 1OUV, Subunit A, Seq Identity:34%, Sel1 repeat

AA: 447-482, PDBID: 1OUV, Subunit A, Seq Identity:38%, Sel1 repeat

AA: 483-518, PDBID: 1KLX, Subunit A, Seq Identity:38%, Sel1 repeat

AA: 627-662, PDBID: 1OUV, Subunit A, Seq Identity:33%, Sel1 repeat

AA: 664-698, PDBID: 1OUV, Subunit A, Seq Identity:34%, Sel1 repeat

UniProt annotation for SE1L1_HUMAN » Protein sel-1 homolog 1
FUNCTION: May play a role in Notch signaling (By similarity). May be involved in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins.

SUBUNIT: Part of a complex containing SEL1L, SYVN1 and DERL2. May form a complex with ERLEC1, HSPA5, OS9, and SYVN1. Interacts with FOXRED2 and EDEM1.

TISSUE SPECIFICITY: Highly expressed in pancreas.

UniProt features for SE1L1_HUMAN » Protein sel-1 homolog 1
SIGNAL 1 21 Potential.
CHAIN 22 794 Protein sel-1 homolog 1.
DOMAIN 122 170 Fibronectin type-II.
REPEAT 183 218 Sel1-like 1.
REPEAT 219 254 Sel1-like 2.
REPEAT 255 290 Sel1-like 3.
REPEAT 291 326 Sel1-like 4.
REPEAT 373 409 Sel1-like 5.
REPEAT 410 446 Sel1-like 6.
REPEAT 447 482 Sel1-like 7.
REPEAT 483 518 Sel1-like 8.
REPEAT 519 554 Sel1-like 9.
REPEAT 627 662 Sel1-like 10.
REPEAT 664 699 Sel1-like 11.
REGION 22 737 Interaction with ERLEC1, OS9 and SYVN1.
REGION 738 794 Mediates retention to the endoplasmic reticulum.
DISULFID 127 153 By similarity.
DISULFID 141 168 By similarity.
Amino Acid Sequence for SE1L1_HUMAN » Protein sel-1 homolog 1
MRVRIGLTLL LCAVLLSLAS ASSDEEGSQD ESLDSKTTLT SDESVKDHTT AGRVVAGQIF LDSEESELES SIQEEEDSLK SQEGESVTED ISFLESPNPE NKDYEEPKKV RKPALTAIEG TAHGEPCHFP FLFLDKEYDE CTSDGREDGR LWCATTYDYK ADEKWGFCET EEEAAKRRQM QEAEMMYQTG MKILNGSNKK SQKREAYRYL QKAASMNHTK ALERVSYALL FGDYLPQNIQ AAREMFEKLT EEGSPKGQTA LGFLYASGLG VNSSQAKALV YYTFGALGGN LIAHMVLGYR YWAGIGVLQS CESALTHYRL VANHVASDIS LTGGSVVQRI RLPDEVENPG MNSGMLEEDL IQYYQFLAEK GDVQAQVGLG QLHLHGGRGV EQNHQRAFDY FNLAANAGNS HAMAFLGKMY SEGSDIVPQS NETALHYFKK AADMGNPVGQ SGLGMAYLYG RGVQVNYDLA LKYFQKAAEQ GWVDGQLQLG SMYYNGIGVK RDYKQALKYF NLASQGGHIL AFYNLAQMHA SGTGVMRSCH TAVELFKNVC ERGRWSERLM TAYNSYKDGD YNAAVIQYLL LAEQGYEVAQ SNAAFILDQR EASIVGENET YPRALLHWNR AASQGYTVAR IKLGDYHFYG FGTDVDYETA FIHYRLASEQ QHSAQAMFNL GYMHEKGLGI KQDIHLAKRF YDMAAEASPD AQVPVFLALC KLGVVYFLQY IRETNIRDMF TQLDMDQLLG PEWDLYLMTI IALLLGTVIA YRQRQHQDMP APRPPGPRPA PPQQEGPPEQ QPPQ