SDK2_HUMAN » Protein sidekick-2

SDK2_HUMAN » Protein sidekick-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SDK2_HUMAN » Protein sidekick-2 »
Hydrophobic Thickness 35.6 ± 4.8 Å
Tilt Angle 29 ± 21°
ΔGtransfer -34.1 kcal/mol
ΔGfold -31.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1926-1954 (1925-1961)
Pathways none
PDB 1wfo (1281-1397), 1wf5 (580-687), 1wfn (885-990), 1wis (983-1093)
OPM none
Complexes none
Interactions none
Domains

AA: 114-203, PDBID: 2K1M, Subunit A, Seq Identity:30%, Immunoglobulin I-set domain

AA: 214-287, PDBID: 2OM5, Subunit A, Seq Identity:43%, Immunoglobulin domain

AA: 308-397, PDBID: 3PXH, Subunit A, Seq Identity:34%, Immunoglobulin I-set domain

AA: 402-492, PDBID: 2DM3, Subunit A, Seq Identity:34%, Immunoglobulin I-set domain

AA: 497-572, PDBID: 2EO9, Subunit A, Seq Identity:33%, Immunoglobulin domain

AA: 592-677, PDBID: 1WF5, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 692-779, PDBID: 1X5H, Subunit A, Seq Identity:37%, Fibronectin type III domain

AA: 793-883, PDBID: 1X5H, Subunit A, Seq Identity:31%, Fibronectin type III domain

AA: 896-980, PDBID: 1WFN, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 994-1083, PDBID: 1WIS, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 1098-1187, PDBID: 2X10, Subunit A, Seq Identity:32%, Fibronectin type III domain

AA: 1201-1288, PDBID: 2ED9, Subunit A, Seq Identity:34%, Fibronectin type III domain

AA: 1302-1387, PDBID: 1WFO, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 1402-1488, PDBID: 1WF5, Subunit A, Seq Identity:35%, Fibronectin type III domain

AA: 1503-1611, PDBID: 1VA9, Subunit A, Seq Identity:26%, Fibronectin type III domain

AA: 1625-1712, PDBID: 4HLJ, Subunit A, Seq Identity:35%, Fibronectin type III domain

AA: 1725-1811, PDBID: 1FNH, Subunit A, Seq Identity:30%, Fibronectin type III domain

AA: 1825-1912, PDBID: 2DJU, Subunit A, Seq Identity:29%, Fibronectin type III domain

UniProt annotation for SDK2_HUMAN » Protein sidekick-2
FUNCTION: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons.
UniProt features for SDK2_HUMAN » Protein sidekick-2
SIGNAL 1 20 Potential.
CHAIN 21 2172 Protein sidekick-2.
DOMAIN 26 108 Ig-like C2-type 1.
DOMAIN 113 200 Ig-like C2-type 2.
DOMAIN 215 294 Ig-like C2-type 3.
DOMAIN 308 396 Ig-like C2-type 4.
DOMAIN 402 491 Ig-like C2-type 5.
DOMAIN 496 585 Ig-like C2-type 6.
DOMAIN 590 683 Fibronectin type-III 1.
DOMAIN 690 786 Fibronectin type-III 2.
DOMAIN 791 890 Fibronectin type-III 3.
DOMAIN 895 986 Fibronectin type-III 4.
DOMAIN 993 1089 Fibronectin type-III 5.
DOMAIN 1096 1194 Fibronectin type-III 6.
DOMAIN 1199 1294 Fibronectin type-III 7.
DOMAIN 1301 1393 Fibronectin type-III 8.
DOMAIN 1400 1496 Fibronectin type-III 9.
DOMAIN 1501 1617 Fibronectin type-III 10.
DOMAIN 1623 1719 Fibronectin type-III 11.
DOMAIN 1724 1818 Fibronectin type-III 12.
DOMAIN 1825 1918 Fibronectin type-III 13.
DISULFID 48 91 By similarity.
DISULFID 237 284 By similarity.
DISULFID 330 380 By similarity.
DISULFID 423 475 By similarity.
DISULFID 517 569 By similarity.
Amino Acid Sequence for SDK2_HUMAN » Protein sidekick-2
MWGLLIWTLL ALHQIRAARA QDDVSPYFKT EPVRTQVHLE GNRLVLTCMA EGSWPLEFKW LHNNRELTKF SLEYRYMITS LDRTHAGFYR CIVRNRMGAL LQRQTEVQVA DMGSFEEGEK HQSVSHGEAA VIRAPRIASF PQPQVTWFRD GRKIPPSSRA ITLENTLVIL STVAPDAGRY YVQAVNDKNG DNKTSQPITL TVEVGGPADP IAPTIIIPPK NTSVVAGTSE VTLECVANAR PLIKLHIIWK KDGVLLSGGI SDHNRRLTIP NPTGSDAGYY ECEAVLRSSS VPSVVRGAYL SVLEPPQFVK EPERHITAEM EKVVDIPCQA KGVPPPSITW YKDAAVVEVE KLTRFRQRND GGLQISGLVP DDTGMFQCFA RNAAGEVQTS TYLAVTSIAP NITRGPLDST VIDGMSVVLA CETSGAPRPA ITWQKGERIL ASGSVQLPRF TPLESGSLLI SPTHISDAGT YTCLATNSRG VDEASADLVV WARTRITKPP QDQSVIKGTQ ASMVCGVTHD PRVTIRYIWE KDGATLGTES HPRIRLDRNG SLHISQTWSG DIGTYTCRVI SAGGNDSRSA HLRVRQLPHA PEHPVATLST VERRAINLTW TKPFDGNSPL IRYILEMSEN NAPWTVLLAS VDPKATSVTV KGLVPARSYQ FRLCAVNDVG KGQFSKDTER VSLPEEPPTA PPQNVIASGR TNQSIMIQWQ PPPESHQNGI LKGYIIRYCL AGLPVGYQFK NITDADVNNL LLEDLIIWTN YEIEVAAYNS AGLGVYSSKV TEWTLQGVPT VPPGNVHAEA TNSTTIRFTW NAPSPQFING INQGYKLIAW EPEQEEEVTM VTARPNFQDS IHVGFVSGLK KFTEYFTSVL CFTTPGDGPR STPQLVRTHE DVPGPVGHLS FSEILDTSLK VSWQEPGEKN GILTGYRISW EEYNRTNTRV THYLPNVTLE YRVTGLTALT TYTIEVAAMT SKGQGQVSAS TISSGVPPEL PGPPTNLGIS NIGPRSVTLQ FRPGYDGKTS ISRWLVEAQV GVVGEGEEWL LIHQLSNEPD ARSMEVPDLN PFTCYSFRMR QVNIVGTSPP SQPSRKIQTL QAPPDMAPAN VSLRTASETS LWLRWMPLPE MEYNGNPESV GYKIKYSRSD GHGKTLSHVV QDRVERDYTI EDLEEWTEYR VQVQAFNAIG SGPWSQTVVG RTRESVPSSG PTNVSALATT SSSMLVRWSE VPEADRNGLV LGYKVMYKEK DSDTQPRFWL VEGNSSRSAQ LTGLGKYVLY EVQVLAFTRI GDGSPSHPPI LERTLDDVPG PPMGILFPEV RTTSVRLIWQ PPAAPNGIIL AYQITHRLNT TTANTATVEV LAPSARQYTA TGLKPESVYL FRITAQTRKG WGEAAEALVV TTEKRDRPQP PSRPMVQQED VRARSVLLSW EPGSDGLSPV RYYTIQTREL PSGRWALHSA SVSHNASSFI VDRLKPFTSY KFRVKATNDI GDSEFSEESE SLTTLQAAPD EAPTILSVTP HTTTSVLIRW QPPAEDKING ILLGFRIRYR ELLYEGLRGF TLRGINNPGA TWAELTSMYS MRNLSRPSLT QYELDNLNKH RRYEIRMSVY NAVGEGPSSP PQEVFVGEAV PTAAPRNVVV HGATATQLDV TWEPPPLDSQ NGDIQGYKIY FWEAQRGNLT ERVKTLFLAE NSVKLKNLTG YTAYMVSVAA FNAAGDGPRS TPTQGQTQQA APSAPSSVKF SELTTTSVNV SWEAPQFPNG ILEGYRLVYE PCSPVDGVSK IVTVDVKGNS PLWLKVKDLA EGVTYRFRIR AKTFTYGPEI EANVTTGPGE GAPGPPGVPI IVRYSSAIAI HWSSGDPGKG PITRYVIEAR PSDEGLWDIL IKDIPKEVSS YTFSMDILKP GVSYDFRVIA VNDYGFGTPS SPSQSVPAQK ANPFYEEWWF LVVIALVGLI FILLLVFVLI IRGQSKKYAK KTDSGNSAKS GALGHSEMMS LDESSFPALE LNNRRLSVKN SFCRKNGLYT RSPPRPSPGS LHYSDEDVTK YNDLIPAESS SLTEKPSEIS DSQGSDSEYE VDSNHQKAHS FVNHYISDPT YYNSWRRQQK GISRAQAYSY TESDSGEPDH TTVTNSTSTQ QGSLFRPKAS RTPTPQNPPN PPSQQSTLYR PPSSLAPGSR APIAGFSSFV