SDK1_HUMAN » Protein sidekick-1

SDK1_HUMAN » Protein sidekick-1
Magnify SDK1_HUMAN » Protein sidekick-1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SDK1_HUMAN » Protein sidekick-1 »
Hydrophobic Thickness 36.0 ± 4.8 Å
Tilt Angle 0 ± 8°
ΔGtransfer -29.2 kcal/mol
ΔGfold -26.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 2008-2033 (2005-2038)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 104-173, PDBID: 3K0W, Subunit A, Seq Identity:33%, Immunoglobulin domain

AA: 192-278, PDBID: 3PXH, Subunit A, Seq Identity:29%, Immunoglobulin I-set domain

AA: 292-365, PDBID: 1CS6, Subunit A, Seq Identity:34%, Immunoglobulin domain

AA: 386-475, PDBID: 2OM5, Subunit A, Seq Identity:35%, Immunoglobulin I-set domain

AA: 480-570, PDBID: 3ZYO, Subunit A, Seq Identity:39%, Immunoglobulin I-set domain

AA: 575-650, PDBID: 2EO9, Subunit A, Seq Identity:32%, Immunoglobulin domain

AA: 669-755, PDBID: 1WF5, Subunit A, Seq Identity:45%, Fibronectin type III domain

AA: 770-857, PDBID: 2ED9, Subunit A, Seq Identity:34%, Fibronectin type III domain

AA: 871-960, PDBID: 2ED9, Subunit A, Seq Identity:35%, Fibronectin type III domain

AA: 973-1057, PDBID: 1WFN, Subunit A, Seq Identity:65%, Fibronectin type III domain

AA: 1071-1160, PDBID: 1WIS, Subunit A, Seq Identity:64%, Fibronectin type III domain

AA: 1175-1264, PDBID: 1X5I, Subunit A, Seq Identity:32%, Fibronectin type III domain

AA: 1278-1365, PDBID: 2ED9, Subunit A, Seq Identity:40%, Fibronectin type III domain

AA: 1379-1463, PDBID: 1WFO, Subunit A, Seq Identity:54%, Fibronectin type III domain

AA: 1478-1565, PDBID: 2CRZ, Subunit A, Seq Identity:35%, Fibronectin type III domain

AA: 1580-1689, PDBID: 1VA9, Subunit A, Seq Identity:29%, Fibronectin type III domain

AA: 1703-1790, PDBID: 1VA9, Subunit A, Seq Identity:36%, Fibronectin type III domain

AA: 1803-1889, PDBID: 1WFN, Subunit A, Seq Identity:35%, Fibronectin type III domain

AA: 1904-1990, PDBID: 1UEM, Subunit A, Seq Identity:32%, Fibronectin type III domain

UniProt annotation for SDK1_HUMAN » Protein sidekick-1
FUNCTION: Cell adhesion protein that guides axonal terminals to specific synapses in developing neurons. Dysregulation of this protein may play an important role in podocyte dysfunction in HIV- associated nephropathy.

TISSUE SPECIFICITY: Up-regulated in glomeruli in HIV-associated nephropathy. In diseased glomeruli, significantly overexpressed and the expression is no longer restricted to mesangial cells but includes podocytes and parietal epithelial cells.

UniProt features for SDK1_HUMAN » Protein sidekick-1
SIGNAL 1 ? Potential.
CHAIN ? 2213 Protein sidekick-1.
DOMAIN 104 186 Ig-like C2-type 1.
DOMAIN 191 277 Ig-like C2-type 2.
DOMAIN 293 378 Ig-like C2-type 3.
DOMAIN 386 476 Ig-like C2-type 4.
DOMAIN 480 569 Ig-like C2-type 5.
DOMAIN 574 663 Ig-like C2-type 6.
DOMAIN 668 762 Fibronectin type-III 1.
DOMAIN 768 864 Fibronectin type-III 2.
DOMAIN 869 966 Fibronectin type-III 3.
DOMAIN 972 1063 Fibronectin type-III 4.
DOMAIN 1070 1168 Fibronectin type-III 5.
DOMAIN 1173 1271 Fibronectin type-III 6.
DOMAIN 1276 1371 Fibronectin type-III 7.
DOMAIN 1378 1470 Fibronectin type-III 8.
DOMAIN 1477 1572 Fibronectin type-III 9.
DOMAIN 1578 1695 Fibronectin type-III 10.
DOMAIN 1701 1797 Fibronectin type-III 11.
DOMAIN 1802 1896 Fibronectin type-III 12.
DOMAIN 1903 1996 Fibronectin type-III 13.
DISULFID 126 169 By similarity.
DISULFID 315 362 By similarity.
DISULFID 408 458 By similarity.
DISULFID 501 553 By similarity.
DISULFID 595 647 By similarity.
Amino Acid Sequence for SDK1_HUMAN » Protein sidekick-1
MARGARPSAA GGGGGGAEPP ERAGPGRPRG SPPGRARPSL APRPGPEPSR PRAAPETPGG DTAGAGRCGG RRAAKLGPGR RGWWALLALQ LHLLRALAQD DVAPYFKTEP GLPQIHLEGN RLVLTCLAEG SWPLEFKWMR DDSELTTYSS EYKYIIPSLQ KLDAGFYRCV VRNRMGALLQ RKSEVQVAYM GSFMDTDQRK TVSQGRAAIL NLLPITSYPR PQVTWFREGH KIIPSNRIAI TLENQLVILA TTTSDAGAYY VQAVNEKNGE NKTSPFIHLS IARDVGTPET MAPTIVVPPG NRSVVAGSSE TTLECIASAR PVEDLSVTWK RNGVRITSGL HSFGRHLTIS NPTSADTGPY VCEAALPGSA FEPARATAFL FIIEPPYFTA EPESRISAEV EETVDIGCQA MGVPLPTLQW YKDAISISRL QNPRYKVLAS GGLRIQKLRP EDSGIFQCFA SNEGGEIQTH TYLDVTNIAP VFTQRPVDTT VTDGMTAILR CEVSGAPKPA ITWKRENHIL ASGSVRIPRF MLLESGGLQI APVFIQDAGN YTCYAANTEG SLNASATLTV WNRTSIVHPP EDHVVIKGTT ATLHCGATHD PRVSLRYVWK KDNVALTPSS TSRIVVEKDG SLLISQTWSG DIGDYSCEIV SEGGNDSRMA RLEVIELPHS PQNLLVSPNS SHSHAVVLSW VRPFDGNSPI LYYIVELSEN SSPWKVHLSN VGPEMTGVTV SGLTPARTYQ FRVCAVNEVG RGQYSAETSR LMLPEEPPSA PPKNIVASGR TNQSIMVQWQ PPPETEHNGV LRGYILRYRL AGLPGEYQQR NITSPEVNYC LVTDLIIWTQ YEIQVAAYNG AGLGVFSRAV TEYTLQGVPT APPQNVQTEA VNSTTIQFLW NPPPQQFING INQGYKLLAW PADAPEAVTV VTIAPDFHGV HHGHITNLKK FTAYFTSVLC FTTPGDGPPS TPQLVWTQED KPGAVGHLSF TEILDTSLKV SWQEPLEKNG IITGYQISWE VYGRNDSRLT HTLNSTTHEY KIQGLSSLTT YTIDVAAVTA VGTGLVTSST ISSGVPPDLP GAPSNLVISN ISPRSATLQF RPGYDGKTSI SRWIVEGQVG AIGDEEEWVT LYEEENEPDA QMLEIPNLTP YTHYRFRMKQ VNIVGPSPYS PSSRVIQTLQ APPDVAPTSV TVRTASETSL RLRWVPLPDS QYNGNPESVG YRIKYWRSDL QSSAVAQVVS DRLEREFTIE ELEEWMEYEL QMQAFNAVGA GPWSEVVRGR TRESVPSAAP ENVSAEAVSS TQILLTWTSV PEQDQNGLIL GYKILFRAKD LDPEPRSHIV RGNHTQSALL AGLRKFVLYE LQVLAFTRIG NGVPSTPLIL ERTKDDAPGP PVRLVFPEVR LTSVRIVWQP PEEPNGIILG YQIAYRLASS SPHTFTTVEV GATVRQFTAT DLAPESAYIF RLSAKTRQGW GEPLEATVIT TEKRERPAPP RELLVPQAEV TARSLRLQWV PGSDGASPIR YFTMQVRELP RGEWQTYSSS ISHEATACVV DRLRPFTSYK LRLKATNDIG DSDFSSETEA VTTLQDVPGE PPGSVSATPH TTSSVLIQWQ PPRDESLNGL LQGYRIYYRE LEYEAGSGTE AKTLKNPIAL HAELTAQSSF KTVNSSSTST MCELTHLKKY RRYEVIMTAY NIIGESPASA PVEVFVGEAA PAMAPQNVQV TPLTASQLEV TWDPPPPESQ NGNIQGYKIY YWEADSQNET EKMKVLFLPE PVVRLKNLTS HTKYLVSISA FNAAGDGPKS DPQQGRTHQA APGAPSFLAF SEITSTTLNV SWGEPAAANG ILQGYRVVYE PLAPVQGVSK VVTVEVRGNW QRWLKVRDLT KGVTYFFRVQ ARTITYGPEL QANITAGPAE GSPGSPRDVL VTKSASELTL QWTEGHSGDT PTTGYVIEAR PSDEGLWDMF VKDIPRSATS YTLSLDKLRQ GVTYEFRVVA VNEAGYGEPS NPSTAVSAQV EAPFYEEWWF LLVMALSSLI VILLVVFALV LHGQNKKYKN CSTGKGISTM EESVTLDNGG FAALELSSRH LNVKSTFSKK NGTRSPPRPS PGGLHYSDED ICNKYNGAVL TESVSLKEKS ADASESEATD SDYEDALPKH SFVNHYMSDP TYYNSWKRRA QGRAPAPHRY EAVAGSEAGA QLHPVITTQS AGGVYTPAGP GARTPLTGFS SFV