SDCB1_HUMAN » Syntenin-1

SDCB1_HUMAN » Syntenin-1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SDCB1_HUMAN » Syntenin-1 » Melanoma differentiation-associated protein 9;MDA-9; Pro-TGF-alpha cytoplasmic domain-interacting protein 18;TACIP18; Scaffold protein Pbp1;Syndecan-binding protein 1;
Hydrophobic Thickness 31.2 ± 7.0 Å
Tilt Angle 29 ± 3°
ΔGtransfer -19.8 kcal/mol
ΔGfold -10.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 254-279 (251-283)
Pathways none
PDB 1ybo (A/B=113-273), 1obz (A/B=113-273), 1n99 (A/B=113-273), 1v1t (A/B=113-273), 1w9e (A/B=113-273), 1w9o (A/B=113-273), 1w9q (A/B=113-273), 1oby (A/B=197-270), 1obx (A=197-270), 1nte (A=197-273), 1r6j (A=197-273)
OPM none
Complexes none
Interactions none
Domains

AA: 114-191, PDBID: 1N99, Subunit B, Seq Identity:100%, PDZ domain (Also known as DHR or GLGF)

UniProt annotation for SDCB1_HUMAN » Syntenin-1
FUNCTION: Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
UniProt features for SDCB1_HUMAN » Syntenin-1
CHAIN 2 298 Syntenin-1.

DOMAIN 114 193 PDZ 1.

DOMAIN 198 273 PDZ 2.

Amino Acid Sequence for SDCB1_HUMAN » Syntenin-1
MSLYPSLEDL KVDKVIQAQT AFSANPANPA ILSEASAPIP HDGNLYPRLY PELSQYMGLS LNEEEIRANV AVVSGAPLQG QLVARPSSIN YMVAPVTGND VGIRRAEIKQ GIREVILCKD QDGKIGLRLK SIDNGIFVQL VQANSPASLV GLRFGDQVLQ INGENCAGWS SDKAHKVLKQ AFGEKITMTI RDRPFERTIT MHKDSTGHVG FIFKNGKITS IVKDSSAARN GLLTEHNICE INGQNVIGLK DSQIADILST SGTVVTITIM PAFIFEHIIK RMAPSIMKSL MDHTIPEV