SDC4_HUMAN » Syndecan-4

SDC4_HUMAN » Syndecan-4
Magnify SDC4_HUMAN » Syndecan-4Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SDC4_HUMAN » Syndecan-4 » SYND4; Amphiglycan;Ryudocan core protein;
Hydrophobic Thickness 35.6 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -54.8 kcal/mol
ΔGfold -28.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 144-172 (143-174)
Pathways

Cell adhesion molecules (KEGG)

ECM-receptor interaction (KEGG)

Proteoglycans in cancer (KEGG)

Signal Transduction (Reactome)

PDB 1ejp (A/B=171-198), 1ejq (A/B=171-198), 1ybo (C/D=182-198), 1oby (P/Q=193-198)
OPM none
Complexes

SDC4:SDC4_HUMAN

Interactions

PECA1, Complex: PECA1:SDC4, PubMed

SDC2, Complex: SDC2:SDC4, PubMed

SDC3, Complex: SDC3:SDC4, PubMed

SDC4, Complex: Homodimer of syndecan-4, PDBID: 1EJP

Domains

AA: 139-196, PDBID: 1EJP, Subunit B, Seq Identity:100%, Syndecan domain

UniProt annotation for SDC4_HUMAN » Syndecan-4
FUNCTION: Cell surface proteoglycan that bears heparan sulfate.

SUBUNIT: Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP.

TISSUE SPECIFICITY: Expressed in epithelial and fibroblastic cells.

UniProt features for SDC4_HUMAN » Syndecan-4
SIGNAL 1 18 Potential.
CHAIN 19 198 Syndecan-4.
Amino Acid Sequence for SDC4_HUMAN » Syndecan-4
MAPARLFALL LFFVGGVAES IRETEVIDPQ DLLEGRYFSG ALPDDEDVVG PGQESDDFEL SGSGDLDDLE DSMIGPEVVH PLVPLDNHIP ERAGSGSQVP TEPKKLEENE VIPKRISPVE ESEDVSNKVS MSSTVQGSNI FERTEVLAAL IVGGIVGILF AVFLILLLMY RMKKKDEGSY DLGKKPIYKK APTNEFYA