SDC3_HUMAN » Syndecan-3

SDC3_HUMAN » Syndecan-3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SDC3_HUMAN » Syndecan-3 » SYND3;
Hydrophobic Thickness 35.6 ± 2.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.7 kcal/mol
ΔGfold -25.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 379-408 (379-413)
Pathways

Cell adhesion molecules (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

CASP, Complex: CASP.CUX1:SDC3, PubMed

EPHB4, Complex: SDC3:EPHB4, PubMed

SDC1, Complex: SDC3:SDC1, PubMed

SDC2, Complex: SDC2:SDC3, PubMed

SDC4, Complex: SDC3:SDC4, PubMed

Domains

AA: 378-440, PDBID: 4GVC, Subunit B, Seq Identity:67%, Syndecan domain

UniProt annotation for SDC3_HUMAN » Syndecan-3
FUNCTION: Cell surface proteoglycan that may bear heparan sulfate (By similarity). May have a role in the organization of cell shape by affecting the actin cytoskeleton, possibly by transferring signals from the cell surface in a sugar-dependent mechanism.

SUBUNIT: Interacts with TIAM1.

TISSUE SPECIFICITY: Expressed in the nervous system, the adrenal gland, and the spleen.

UniProt features for SDC3_HUMAN » Syndecan-3
CHAIN 1 442 Syndecan-3.
SITE 383 384 Cleavage of ectodomain (Potential).
Amino Acid Sequence for SDC3_HUMAN » Syndecan-3
MKPGPPHRAG AAHGAGAGAG AAAGPGARGL LLPPLLLLLL AGRAAGAQRW RSENFERPVD LEGSGDDDSF PDDELDDLYS GSGSGYFEQE SGIETAMRFS PDVALAVSTT PAVLPTTNIQ PVGTPFEELP SERPTLEPAT SPLVVTEVPE EPSQRATTVS TTMATTAATS TGDPTVATVP ATVATATPST PAAPPFTATT AVIRTTGVRR LLPLPLTTVA TARATTPEAP SPPTTAAVLD TEAPTPRLVS TATSRPRALP RPATTQEPDI PERSTLPLGT TAPGPTEVAQ TPTPETFLTT IRDEPEVPVS GGPSGDFELP EEETTQPDTA NEVVAVGGAA AKASSPPGTL PKGARPGPGL LDNAIDSGSS AAQLPQKSIL ERKEVLVAVI VGGVVGALFA AFLVTLLIYR MKKKDEGSYT LEEPKQASVT YQKPDKQEEF YA