SDC2_HUMAN » Syndecan-2

SDC2_HUMAN » Syndecan-2
Magnify SDC2_HUMAN » Syndecan-2Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SDC2_HUMAN » Syndecan-2 » SYND2; Fibroglycan;Heparan sulfate proteoglycan core protein;HSPG;
Hydrophobic Thickness 33.6 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -51.4 kcal/mol
ΔGfold -27.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 144-172 (144-173)
Pathways

Cell adhesion molecules (KEGG)

Malaria (KEGG)

Proteoglycans in cancer (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

CP2CI, Complex: CP2CI:SDC2, PubMed

CSF2R, Complex: CSF2R:SDC2, PubMed

EPHB2, Complex: SDC2:EPHB2, PubMed

SDC1, Complex: SDC2:SDC1, PubMed

SDC3, Complex: SDC2:SDC3, PubMed

SDC4, Complex: SDC2:SDC4, PubMed

TGBR3, Complex: SDC2:TGBR3, PubMed

Domains

AA: 138-199, PDBID: 1EJP, Subunit B, Seq Identity:66%, Syndecan domain

UniProt annotation for SDC2_HUMAN » Syndecan-2
FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).

SUBUNIT: Interacts (via cytoplasmic domain) with SARM1.

UniProt features for SDC2_HUMAN » Syndecan-2
SIGNAL 1 18 Potential.
CHAIN 19 201 Syndecan-2.
SITE 142 143 Cleavage of ectodomain (Potential).
Amino Acid Sequence for SDC2_HUMAN » Syndecan-2
MRRAWILLTL GLVACVSAES RAELTSDKDM YLDNSSIEEA SGVYPIDDDD YASASGSGAD EDVESPELTT SRPLPKILLT SAAPKVETTT LNIQNKIPAQ TKSPEETDKE KVHLSDSERK MDPAEEDTNV YTEKHSDSLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD LGERKPSSAA YQKAPTKEFY A