SDC1_HUMAN » Syndecan-1

SDC1_HUMAN » Syndecan-1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SDC1_HUMAN » Syndecan-1 » SYND1;
Hydrophobic Thickness 37.2 ± 2.6 Å
Tilt Angle 2 ± 1°
ΔGtransfer -36.3 kcal/mol
ΔGfold -18.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 252-278 (249-280)
Pathways

Cell adhesion molecules (KEGG)

ECM-receptor interaction (KEGG)

Malaria (KEGG)

Proteoglycans in cancer (KEGG)

Signal Transduction (Reactome)

PDB 4gvc (B=303-310), 4gvd (C/D=303-310)
OPM none
Complexes none
Interactions

A4, Complex: A4:SDC1, PubMed

EFNB2, Complex: SDC1:EFNB2, PubMed

MMP14, Complex: MMP14:SDC1, PubMed

PECA1, Complex: PECA1:SDC1, PubMed

SDC2, Complex: SDC2:SDC1, PubMed

SDC3, Complex: SDC3:SDC1, PubMed

Domains

AA: 245-308, PDBID: 4GVC, Subunit B, Seq Identity:100%, Syndecan domain

UniProt annotation for SDC1_HUMAN » Syndecan-1
FUNCTION: Cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.

SUBUNIT: Interacts with CDCP1. Interacts (via C-terminus) with TIAM1 (via PDZ domain).

UniProt features for SDC1_HUMAN » Syndecan-1
SIGNAL 1 22 Potential.
CHAIN 23 310 Syndecan-1.
SITE 242 243 Cleavage (By similarity).
Amino Acid Sequence for SDC1_HUMAN » Syndecan-1
MRRAALWLWL CALALSLQPA LPQIVATNLP PEDQDGSGDD SDNFSGSGAG ALQDITLSQQ TPSTWKDTQL LTAIPTSPEP TGLEATAAST STLPAGEGPK EGEAVVLPEV EPGLTAREQE ATPRPRETTQ LPTTHLASTT TATTAQEPAT SHPHRDMQPG HHETSTPAGP SQADLHTPHT EDGGPSATER AAEDGASSQL PAAEGSGEQD FTFETSGENT AVVAVEPDRR NQSPVDQGAT GASQGLLDRK EVLGGVIAGG LVGLIFAVCL VGFMLYRMKK KDEGSYSLEE PKQANGGAYQ KPTKQEEFYA