SCTM1_HUMAN » Secreted and transmembrane protein 1

SCTM1_HUMAN » Secreted and transmembrane protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SCTM1_HUMAN » Secreted and transmembrane protein 1 » Protein K-12;
Hydrophobic Thickness 32.8 ± 2.2 Å
Tilt Angle 21 ± 7°
ΔGtransfer -27.3 kcal/mol
ΔGfold -24.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 148-169 (148-175)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CD7, Complex: SCTM1:CD7, PubMed

Domains none
UniProt annotation for SCTM1_HUMAN » Secreted and transmembrane protein 1
FUNCTION: May be involved in thymocyte signaling.

SUBUNIT: Interacts with CD7.

TISSUE SPECIFICITY: Detected at the highest levels in peripheral blood leukocytes and breast cancer cell lines. Found in leukocytes of the myeloid lineage, with the strongest expression observed in granulocytes and no detectable expression in lymphocytes. Expressed in thymic epithelial cells and fibroblasts.

INDUCTION: By IFNG/IFN-gamma (at protein level).

UniProt features for SCTM1_HUMAN » Secreted and transmembrane protein 1
SIGNAL 1 28 Potential.
CHAIN 29 248 Secreted and transmembrane protein 1.
DISULFID 38 55 Potential.
Amino Acid Sequence for SCTM1_HUMAN » Secreted and transmembrane protein 1
MQTCPLAFPG HVSQALGTLL FLAASLSAQN EGWDSPICTE GVVSVSWGEN TVMSCNISNA FSHVNIKLRA HGQESAIFNE VAPGYFSRDG WQLQVQGGVA QLVIKGARDS HAGLYMWHLV GHQRNNRQVT LEVSGAEPQS APDTGFWPVP AVVTAVFILL VALVMFAWYR CRCSQQRREK KFFLLEPQMK VAALRAGAQQ GLSRASAELW TPDSEPTPRP LALVFKPSPL GALELLSPQP LFPYAADP