SCS2_YEAST » Vesicle-associated membrane protein-associated protein SCS2

SCS2_YEAST » Vesicle-associated membrane protein-associated protein SCS2
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SCS2_YEAST » Vesicle-associated membrane protein-associated protein SCS2 » VAMP-associated protein SCS2; Choline sensitivity suppressor protein 2;VAP homolog 1;
Hydrophobic Thickness 30.0 ± 2.8 Å
Tilt Angle 1 ± 7°
ΔGtransfer -24.8 kcal/mol
ΔGfold -18.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 224-243 (222-243)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ANP1, Complex: SCS2:ANP1

ATG32, Complex: SCS2:ATG32

CP51, Complex: SCS2:CP51

DPM1, Complex: SCS2:DPM1

EMC1, Complex: SCS2:EMC1

EMP24, Complex: EMP24:SCS2

ERG2, Complex: ERG2:SCS2

ERP1, Complex: ERP1:SCS2

FDFT, Complex: FDFT:SCS2

GOSR1, Complex: GOSR1:SCS2

GPI8, Complex: SCS2:GPI8

GSF2, Complex: SCS2:GSF2

MMM1, Complex: SCS2:MMM1

MTC4, Complex: SCS2:MTC4

OST1, Complex: SCS2:OST1

OSTB, Complex: SCS2:OSTB

SC6B1, Complex: SC6B1:SCS2

SCS22, Complex: SCS2:SCS22, PubMed

SEC66, Complex: SCS2:SEC66

TMEDA, Complex: TMEDA:SCS2

TOM70, Complex: TOM70:SCS2

USE1, Complex: USE1:SCS2

VOA1, Complex: SCS2:VOA1

YHO0, Complex: SCS2:YHO0, PubMed

Domains

AA: 3-110, PDBID: 1Z9L, Subunit A, Seq Identity:33%, MSP (Major sperm protein) domain

UniProt annotation for SCS2_YEAST » Vesicle-associated membrane protein-associated protein SCS2
FUNCTION: Targets proteins containing a FFAT motif to endoplasmic reticulum membranes. Regulates phospholipid biosynthesis by modulating the subcellular localization of the transcriptional repressor OPI1.

SUBUNIT: Interacts with OPI1.

DOMAIN: The MSP domain is required for binding to the FFAT motif of target proteins.

MISCELLANEOUS: Present with 3497 molecules/cell in log phase SD medium.

UniProt features for SCS2_YEAST » Vesicle-associated membrane protein-associated protein SCS2
CHAIN 2 244 Vesicle-associated membrane protein- associated protein SCS2.
DOMAIN 3 126 MSP.
Amino Acid Sequence for SCS2_YEAST » Vesicle-associated membrane protein-associated protein SCS2
MSAVEISPDV LVYKSPLTEQ STEYASISNN SDQTIAFKVK TTAPKFYCVR PNAAVVAPGE TIQVQVIFLG LTEEPAADFK CRDKFLVITL PSPYDLNGKA VADVWSDLEA EFKQQAISKK IKVKYLISPD VHPAQNQNIQ ENKETVEPVV QDSEPKEVPA VVNEKEVPAE PETQPPVQVK KEEVPPVVQK TVPHENEKQT SNSTPAPQNQ IKEAATVPAE NESSSMGIFI LVALLILVLG WFYR