SCS22_YEAST » Vesicle-associated membrane protein-associated protein SCS22

SCS22_YEAST » Vesicle-associated membrane protein-associated protein SCS22
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SCS22_YEAST » Vesicle-associated membrane protein-associated protein SCS22 » VAMP-associated protein SCS22; VAP homolog 2;
Hydrophobic Thickness 30.6 ± 1.6 Å
Tilt Angle 5 ± 2°
ΔGtransfer -21.4 kcal/mol
ΔGfold -12.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 155-175 (153-175)
Pathways none
PDB none
OPM none
Complexes none
Interactions

SCS2, Complex: SCS2:SCS22, PubMed

Domains

AA: 1-106, PDBID: 2MDK, Subunit A, Seq Identity:31%, MSP (Major sperm protein) domain

UniProt annotation for SCS22_YEAST » Vesicle-associated membrane protein-associated protein SCS22
FUNCTION: Targets proteins containing a FFAT motif to membranes (By similarity). Involved in regulation of phospholipid metabolism.

DOMAIN: The MSP domain is required for binding to the FFAT motif of target proteins.

MISCELLANEOUS: Present with 358 molecules/cell in log phase SD medium.

UniProt features for SCS22_YEAST » Vesicle-associated membrane protein-associated protein SCS22
CHAIN 1 175 Vesicle-associated membrane protein- associated protein SCS22.
DOMAIN 1 125 MSP.
Amino Acid Sequence for SCS22_YEAST » Vesicle-associated membrane protein-associated protein SCS22
MRIVPEKLVF KAPLNKQSTE YIKLENDGEK RVIFKVRTSA PTKYCVRPNV AIIGAHESVN VQIVFLGLPK STADDEMDQK RDKFLIVTLP IPAAYQNVED GELLSDWPNL EEQYKDDIVF KKIKIFHSVL PKRKPSGNHD AESARAPSAG NGQSLSSRAL LIITVIALLV GWIYY