SCIMP_HUMAN » SLP adapter and CSK-interacting membrane protein

SCIMP_HUMAN » SLP adapter and CSK-interacting membrane protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SCIMP_HUMAN » SLP adapter and CSK-interacting membrane protein » SLP65/SLP76, Csk-interacting membrane protein;
Hydrophobic Thickness 34.4 ± 4.8 Å
Tilt Angle 7 ± 18°
ΔGtransfer -24.8 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 18-41 (18-50)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 12-143, SCIMP protein

UniProt annotation for SCIMP_HUMAN » SLP adapter and CSK-interacting membrane protein
FUNCTION: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation.

SUBUNIT: Interacts with CD37, CD53 and CD81. Interacts with BLNK and GRB2 isoform 1. Interacts (via prolin-rich region) with LYN (via SH3 domain). Interacts with CSK (via SH2 domain).

TISSUE SPECIFICITY: Expressed in antigen-presenting cells, like peripheral blood leukocytes and monocyte-derived dendritic cells (MDDC) (at protein level). Highly expressed in lymph nodes and spleen. Expressed in antigen-presenting cells. Faintly expressed in the majority of nonimmune system tissues.

UniProt features for SCIMP_HUMAN » SLP adapter and CSK-interacting membrane protein
CHAIN 1 145 SLP adapter and CSK-interacting membrane protein.
Amino Acid Sequence for SCIMP_HUMAN » SLP adapter and CSK-interacting membrane protein
MDTFTVQDST AMSWWRNNFW IILAVAIIVV SVGLGLILYC VCKWQLRRGK KWEIAKPLKH KQVDEEKMYE NVLNESPVQL PPLPPRNWPS LEDSSPQEAP SQPPATYSLV NKVKNKKTVS IPSYIEPEDD YDDVEIPANT EKASF