SCF_HUMAN » Kit ligand

SCF_HUMAN » Kit ligand
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SCF_HUMAN » Kit ligand » Mast cell growth factor;MGF; Stem cell factor;SCF; c-Kit ligand;
Hydrophobic Thickness 34.8 ± 3.2 Å
Tilt Angle 4 ± 12°
ΔGtransfer -23.7 kcal/mol
ΔGfold -19.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 215-238 (210-240)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Melanogenesis (KEGG)

Pathways in cancer (KEGG)

PI3K-Akt signaling pathway (KEGG)

Signal Transduction (Reactome)

PDB 1scf (A/B/C/D=1-273), 1exz (A/B/C/D=26-166), 2e9w (C/D=26-166)
OPM none
Complexes

SCF:KIT_HUMAN

SCF:SCF_HUMAN

Interactions

EPOR, Complex: SCF:EPOR, PubMed

FLT3L, Complex: SCF:FLT3L, PubMed

KIT, Complex: KIT:SCF, PDBID: 2e9w

SCF, Complex: Homodimer of KIT ligand, PDBID: 1SCF

Domains

AA: 1-273, PDBID: 1EXZ, Subunit A, Seq Identity:100%, Stem cell factor

UniProt annotation for SCF_HUMAN » Kit ligand
FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5- trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

SUBUNIT: Homodimer, non-covalently linked (Probable). Heterotetramer with KIT, binding two KIT molecules; thereby mediates KIT dimerization and subsequent activation by autophosphorylation.

DEVELOPMENTAL STAGE: Acts in the early stages of hematopoiesis.

DISEASE: Hyperpigmentation with or without hypopigmentation, familial progressive (FPHH) OMIM: A disorder characterized by hyperpigmented patches in the skin, present in early infancy and increasing in size and number with age. Hyperpigmentation has variable intensity, and sometimes is associated with cafe-au-lait macules and larger hypopigmented ash-leaf macules. mutations affecting the gene represented in this entry.

UniProt features for SCF_HUMAN » Kit ligand
SIGNAL 1 25
CHAIN 26 273 Kit ligand.
CHAIN 26 190 Soluble KIT ligand.
SITE 97 97 Not glycosylated.
DISULFID 29 114
DISULFID 68 163
Amino Acid Sequence for SCF_HUMAN » Kit ligand
MKKTQTWILT CIYLQLLLFN PLVKTEGICR NRVTNNVKDV TKLVANLPKD YMITLKYVPG MDVLPSHCWI SEMVVQLSDS LTDLLDKFSN ISEGLSNYSI IDKLVNIVDD LVECVKENSS KDLKKSFKSP EPRLFTPEEF FRIFNRSIDA FKDFVVASET SDCVVSSTLS PEKDSRVSVT KPFMLPPVAA SSLRNDSSSS NRKAKNPPGD SSLHWAAMAL PALFSLIIGF AFGALYWKKR QPSLTRAVEN IQINEEDNEI SMLQEKEREF QEV