SCAR5_HUMAN » Scavenger receptor class A member 5

SCAR5_HUMAN » Scavenger receptor class A member 5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
SCAR5_HUMAN » Scavenger receptor class A member 5 » Scavenger receptor hlg;
Hydrophobic Thickness 34.4 ± 3.6 Å
Tilt Angle 29 ± 1°
ΔGtransfer -25.2 kcal/mol
ΔGfold -21.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 55-82 (54-83)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 304-358, PDBID: 2JG8, Subunit B, Seq Identity:46%, Collagen triple helix repeat (20 copies)

AA: 327-386, PDBID: 1M7L, Subunit A, Seq Identity:44%, Collagen triple helix repeat (20 copies)

AA: 396-493, PDBID: 1BY2, Subunit A, Seq Identity:45%, Scavenger receptor cysteine-rich domain

UniProt annotation for SCAR5_HUMAN » Scavenger receptor class A member 5
FUNCTION: Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1) (By similarity).

SUBUNIT: Homotrimer.

UniProt features for SCAR5_HUMAN » Scavenger receptor class A member 5
CHAIN 1 495 Scavenger receptor class A member 5.
DOMAIN 315 374 Collagen-like.
DOMAIN 393 493 SRCR.
COILED 89 115 Potential.
DISULFID 418 482 By similarity.
DISULFID 431 492 By similarity.
DISULFID 462 472 By similarity.
Amino Acid Sequence for SCAR5_HUMAN » Scavenger receptor class A member 5
MENKAMYLHT VSDCDTSSIC EDSFDGRSLS KLNLCEDGPC HKRRASICCT QLGSLSALKH AVLGLYLLVF LILVGIFILA VSRPRSSPDD LKALTRNVNR LNESFRDLQL RLLQAPLQAD LTEQVWKVQD ALQNQSDSLL ALAGAVQRLE GALWGLQAQA VQTEQAVALL RDRTGQQSDT AQLELYQLQV ESNSSQLLLR RHAGLLDGLA RRVGILGEEL ADVGGVLRGL NHSLSYDVAL HRTRLQDLRV LVSNASEDTR RLRLAHVGME LQLKQELAML NAVTEDLRLK DWEHSIALRN ISLAKGPPGP KGDQGDEGKE GRPGIPGLPG LRGLPGERGT PGLPGPKGDD GKLGATGPMG MRGFKGDRGP KGEKGEKGDR AGDASGVEAP MMIRLVNGSG PHEGRVEVYH DRRWGTVCDD GWDKKDGDVV CRMLGFRGVE EVYRTARFGQ GTGRIWMDDV ACKGTEETIF RCSFSKWGVT NCGHAEDASV TCNRH