SC6B1_YEAST » Protein transport protein SBH1

SC6B1_YEAST » Protein transport protein SBH1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SC6B1_YEAST » Protein transport protein SBH1 » Sec61 complex subunit SBH1;Sec61 complex subunit beta;
Hydrophobic Thickness 30.8 ± 3.4 Å
Tilt Angle 34 ± 8°
ΔGtransfer -26.5 kcal/mol
ΔGfold -18.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 54-78 (54-78)
Pathways

Phagosome (KEGG)

Protein export (KEGG)

Protein processing in endoplasmic reticulum (KEGG)

Sphingolipid metabolism (KEGG)

PDB none
OPM none
Complexes none
Interactions

CY1, Complex: SC6B1:CY1

GPI8, Complex: SC6B1:GPI8

KTR6, Complex: KTR6:SC6B1

MGA2, Complex: SC6B1:MGA2, PubMed

OST1, Complex: OST1:SC6B1, PubMed

OST4, Complex: OST4:SC6B1, PubMed

OSTB, Complex: OSTB:SC6B1, PubMed

SC61G, Complex: SC61G:SC6B1, PubMed

SC6B2, Complex: SC6B1:SC6B2

SCS2, Complex: SC6B1:SCS2

SEC66, Complex: SC61A:SC61G:SEC62:SEC66:SEC72:SC6B1, PubMed

SSH4, Complex: SC6B1:SSH4

VAM3, Complex: SC6B1:VAM3

Domains

AA: 35-75, PDBID: 2WW9, Subunit C, Seq Identity:72%, Sec61beta family

UniProt annotation for SC6B1_YEAST » Protein transport protein SBH1
FUNCTION: Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post- translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP- independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2.

SUBUNIT: Component of the heterotrimeric Sec61 complex, which is composed of SSH1, SBH1 and SSS1. Presumably three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aqueous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. The Sec61 complex is part of a channel-forming translocon complex whose composition seem to change dependent upon different functional states. During post-translational ER import the Sec61 complex associates with the Sec62/63 complex to form the Sec complex. SBH1 interacts OST2, OST4 and WBP1 components of the OT complex.

UniProt features for SC6B1_YEAST » Protein transport protein SBH1
CHAIN 1 82 Protein transport protein SBH1.
Amino Acid Sequence for SC6B1_YEAST » Protein transport protein SBH1
MSSPTPPGGQ RTLQKRKQGS SQKVAASAPK KNTNSNNSIL KIYSDEATGL RVDPLVVLFL AVGFIFSVVA LHVISKVAGK LF