SC61G_YEAST » Protein transport protein SSS1

SC61G_YEAST » Protein transport protein SSS1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SC61G_YEAST » Protein transport protein SSS1 » Sec61 complex subunit SSS1;Sec61 complex subunit gamma;Ssh1 complex subunit SSS1;Ssh1 complex subunit gamma;
Hydrophobic Thickness 30.8 ± 3.8 Å
Tilt Angle 39 ± 29°
ΔGtransfer -18.7 kcal/mol
ΔGfold -11.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 46-71 (46-73)
Pathways

Phagosome (KEGG)

Protein export (KEGG)

Protein processing in endoplasmic reticulum (KEGG)

PDB 2ww9 (1-80), 2wwa (1-80)
OPM 2wwb (CANFA), 4cg5 (CANFA), 4cg6 (CANFA), 4cg7 (CANFA), 2wwa, 2ww9
Complexes

S61A1:SC61G:SC61B_CANFA

Interactions

EMP24, Complex: EMP24:SC61G, PubMed

ERP2, Complex: SC61G:ERP2, PubMed

OST1, Complex: OST1:SC61G, PubMed

OST4, Complex: SC61G:OST4, PubMed

OSTB, Complex: OSTB:SC61G, PubMed

RMP1, Complex: RMP1:SC61G

SC6B1, Complex: SC61G:SC6B1, PubMed

SC6B2, Complex: SSH1:SC61G:SC61A:SC6B2:SEC62, PubMed

SEC66, Complex: SC61A:SC61G:SEC62:SEC66:SEC72:SC6B1, PubMed

Domains

AA: 26-79, PDBID: 2WW9, Subunit B, Seq Identity:100%, SecE/Sec61-gamma subunits of protein translocation complex

UniProt annotation for SC61G_YEAST » Protein transport protein SSS1
FUNCTION: Part of the Sec61 complex, which is the major component of channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post- translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP- independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2. Also part of the Ssh1 complex, which probably is the major component of a channel-forming translocon complex that may function exclusively in the cotranslational pathway of protein ER import.

SUBUNIT: Component of the heterotrimeric Sec61 complex, which is composed of SSH1, SBH1 and SSS1. Presumably three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aqueous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. The Sec61 complex is part of a channel-forming translocon complex whose composition seem to change dependent upon different functional states. During post-translational ER import the Sec61 complex associates with the Sec62/63 complex to form the Sec complex. SSH1 is a component of the heterotrimeric Ssh1 complex, which is composed of SSH1, SBH2 and SSS1. SSS1 interacts with OST1, OST4, SWP1 and WBP1, components of the OT complex.

UniProt features for SC61G_YEAST » Protein transport protein SSS1
CHAIN 1 80 Protein transport protein SSS1.
Amino Acid Sequence for SC61G_YEAST » Protein transport protein SSS1
MARASEKGEE KKQSNNQVEK LVEAPVEFVR EGTQFLAKCK KPDLKEYTKI VKAVGIGFIA VGIIGYAIKL IHIPIRYVIV