SC61B_HUMAN » Protein transport protein Sec61 subunit beta

SC61B_HUMAN » Protein transport protein Sec61 subunit beta
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SC61B_HUMAN » Protein transport protein Sec61 subunit beta »
Hydrophobic Thickness 30.0 ± 3.3 Å
Tilt Angle 31 ± 1°
ΔGtransfer -25.6 kcal/mol
ΔGfold -14.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 70-91 (70-93)
Pathways

Gene Expression (Reactome)

Immune System (Reactome)

Phagosome (KEGG)

Protein export (KEGG)

Protein processing in endoplasmic reticulum (KEGG)

Vibrio cholerae infection (KEGG)

PDB none
OPM 2wwb (CANFA), 4cg5 (CANFA), 4cg6 (CANFA), 4cg7 (CANFA)
Complexes

S61A1:SC61G:SC61B_CANFA

Interactions

BMR1A, Complex: SC61B:BMR1A

EDEM1, Complex: EDEM1:SC61B, PubMed

EGFR, Complex: EGFR:SC61B, PubMed

ERLN2, Complex: SC61B:ERLN2

ESR1, Complex: SC61B:ESR1, PubMed

ITA4, Complex: ITA4:SC61B, PubMed

OST4, Complex: SC61B:OST4

RAGE, Complex: SC61B:RAGE, PubMed

SC61G, Complex: S61A1:SC61G:SC61B, PDBID: 4CG5

SC61G, Complex: S61A2:SC61G:S61A1:SC61B, PubMed

SERP1, Complex: SC61B:SERP1, PubMed

SSRA, Complex: SC61B:SSRA, PubMed

SSRB, Complex: SSRB:SC61B, PubMed

VCAM1, Complex: VCAM1:SC61B, PubMed

Domains

AA: 51-91, PDBID: 2WWB, Subunit C, Seq Identity:100%, Sec61beta family

UniProt annotation for SC61B_HUMAN » Protein transport protein Sec61 subunit beta
FUNCTION: Necessary for protein translocation in the endoplasmic reticulum.

SUBUNIT: Heterotrimeric complex composed of SEC61-alpha, SEC61- beta and SEC61-gamma. Part of a complex composed of SEC61, SEC62 and SEC63. Interacts with SEC62.

UniProt features for SC61B_HUMAN » Protein transport protein Sec61 subunit beta
CHAIN 2 96 Protein transport protein Sec61 subunit beta.
Amino Acid Sequence for SC61B_HUMAN » Protein transport protein Sec61 subunit beta
MPGPTPSGTN VGSSGRSPSK AVAARAAGST VRQRKNASCG TRSAGRTTSA GTGGMWRFYT EDSPGLKVGP VPVLVMSLLF IASVFMLHIW GKYTRS