SC22B_HUMAN » Vesicle-trafficking protein SEC22b

SC22B_HUMAN » Vesicle-trafficking protein SEC22b
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
SC22B_HUMAN » Vesicle-trafficking protein SEC22b » ER-Golgi SNARE of 24 kDa;ERS-24; ERS24; SEC22 vesicle-trafficking protein homolog B;SEC22 vesicle-trafficking protein-like 1;
Hydrophobic Thickness 31.2 ± 3.5 Å
Tilt Angle 24 ± 7°
ΔGtransfer -24.8 kcal/mol
ΔGfold -16.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 191-213 (189-214)
Pathways

Legionellosis (KEGG)

Phagosome (KEGG)

SNARE interactions in vesicular transport (KEGG)

PDB 3egd (C=1-157), 3egx (C=1-157), 2nup (C=1-195), 2nut (C=1-195)
OPM none
Complexes

BET1:SC22B:SC24A:SC23A_HUMAN

Interactions

B3GA3, Complex: SC22B:B3GA3, PubMed

BET1, Complex: BET1:SC22B:SC23A:SC24A, PDBID: 3egx

CREB3, Complex: SC22B:CREB3

ESR1, Complex: ESR1:SC22B, PubMed

GOSR1, Complex: GOSR1:SC22B, PubMed

STIM1, Complex: SC22B:STIM1, PubMed

STX18, Complex: STX18:SC22B, PubMed

STX4, Complex: STX4:SC22B, PubMed

STX5, Complex: SC22B:STX5, PubMed

TMED9, Complex: TMED9:SC22B, PubMed

TMEDA, Complex: TMEDA:SC22B, PubMed

TMEM9, Complex: TMEM9:SC22B, PubMed

VAMP2, Complex: SC22B:VAMP2, PubMed

VAPB, Complex: SC22B:VAPB, PubMed

Domains

AA: 37-117, PDBID: 2NUP, Subunit C, Seq Identity:100%, Regulated-SNARE-like domain

AA: 131-215, PDBID: 2NUP, Subunit C, Seq Identity:100%, Synaptobrevin

UniProt annotation for SC22B_HUMAN » Vesicle-trafficking protein SEC22b
FUNCTION: SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.

SUBUNIT: Interacts with STX17 (By similarity). Component of two distinct SNARE complexes consisting of STX5, GOSR2/BOS1, BET1 and SEC22B or STX18, USE1L, BNIP1/SEC20L and SEC22B. YKT6 can probably replace SEC22B in either complex.

UniProt features for SC22B_HUMAN » Vesicle-trafficking protein SEC22b
CHAIN 2 215 Vesicle-trafficking protein SEC22b.
DOMAIN 6 119 Longin.
DOMAIN 134 194 v-SNARE coiled-coil homology.
Amino Acid Sequence for SC22B_HUMAN » Vesicle-trafficking protein SEC22b
MVLLTMIARV ADGLPLAASM QEDEQSGRDL QQYQSQAKQL FRKLNEQSPT RCTLEAGAMT FHYIIEQGVC YLVLCEAAFP KKLAFAYLED LHSEFDEQHG KKVPTVSRPY SFIEFDTFIQ KTKKLYIDSR ARRNLGSINT ELQDVQRIMV ANIEEVLQRG EALSALDSKA NNLSSLSKKY RQDAKYLNMR STYAKLAAVA VFFIMLIVYV RFWWL