SAFA_ECOLI » Two-component-system connector protein SafA

SAFA_ECOLI » Two-component-system connector protein SafA
Magnify SAFA_ECOLI » Two-component-system connector protein SafAEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
SAFA_ECOLI » Two-component-system connector protein SafA » Regulatory protein b1500;Sensor associating factor A;
Hydrophobic Thickness 34.4 ± 4.4 Å
Tilt Angle 8 ± 7°
ΔGtransfer -24.0 kcal/mol
ΔGfold -22.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 16-40 (14-40)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 1-65, Two-component-system connector protein

UniProt annotation for SAFA_ECOLI » Two-component-system connector protein SafA
FUNCTION: Connects the signal transduction between the two- component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions.

SUBUNIT: Interacts with PhoQ.

INDUCTION: By acid stress, via the EvgS/EvgA system.

UniProt features for SAFA_ECOLI » Two-component-system connector protein SafA
CHAIN 1 65 Two-component-system connector protein SafA.
Amino Acid Sequence for SAFA_ECOLI » Two-component-system connector protein SafA
MHATTVKNKI TQRDNYKEIM SAIVVVLLLT LTLIAIFSAI DQLSISEMGR IARDLTHFII NSLQG