RPRM_HUMAN » Protein reprimo

RPRM_HUMAN » Protein reprimo
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Topology in Membrane
Topologyouter side
inner side
RPRM_HUMAN » Protein reprimo »
Hydrophobic Thickness 32.4 ± 4.0 Å
Tilt Angle 38 ± 1°
ΔGtransfer -27.9 kcal/mol
ΔGfold -19.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 53-81 (48-85)
Pathways

p53 signaling pathway (KEGG)

PDB none
OPM none
Complexes none
Interactions

CREB3, Complex: RPRM:CREB3

FATE1, Complex: RPRM:FATE1

Domains none
UniProt annotation for RPRM_HUMAN » Protein reprimo
FUNCTION: May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex (By similarity).

INDUCTION: By p53/TP53, following X-ray irradiation.

MISCELLANEOUS: "Reprimo" signifies stop/repress.

UniProt features for RPRM_HUMAN » Protein reprimo
CHAIN 1 109 Protein reprimo.
Amino Acid Sequence for RPRM_HUMAN » Protein reprimo
MNPALGNQTD VAGLFLANSS EALERAVRCC TQASVVTDDG FAEGGPDERS LYIMRVVQIA VMCVLSLTVV FGIFFLGCNL LIKSEGMINF LVKDRRPSKE VEAVVVGPY