ROT1_YEAST » Protein ROT1

ROT1_YEAST » Protein ROT1
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
ROT1_YEAST » Protein ROT1 » Reversal of TOR2 lethality protein 1;
Hydrophobic Thickness 29.8 ± 2.0 Å
Tilt Angle 2 ± 2°
ΔGtransfer -12.8 kcal/mol
ΔGfold -5.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 238-256 (235-256)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ALG5, Complex: ALG5:ROT1, PubMed

BIG1, Complex: BIG1:ROT1, PubMed

CALX, Complex: ROT1:CALX, PubMed

CWH41, Complex: CWH41:ROT1

EMP24, Complex: EMP24:ROT1

GDA1, Complex: GDA1:ROT1

HLJ1, Complex: HLJ1:ROT1

HOC1, Complex: HOC1:ROT1

KEX1, Complex: KEX1:ROT1

KEX2, Complex: KEX2:ROT1

KRE6, Complex: KRE6:ROT1, PubMed

MNN11, Complex: MNN11:ROT1

MNN2, Complex: ROT1:MNN2

SAC1, Complex: SAC1:ROT1, PubMed

SEC66, Complex: SEC66:ROT1

YND1, Complex: YND1:ROT1

Domains

AA: 31-253, Chaperone for protein-folding within the ER, fungal

UniProt annotation for ROT1_YEAST » Protein ROT1
FUNCTION: Required for normal levels of the cell wall 1,6-beta- glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies. Controls actin cytoskeleton polarization to the mother-bud neck and CLB2 protein stability.

MISCELLANEOUS: Present with 2360 molecules/cell in log phase SD medium.

UniProt features for ROT1_YEAST » Protein ROT1
SIGNAL 1 24 Potential.
CHAIN 25 256 Protein ROT1.
Amino Acid Sequence for ROT1_YEAST » Protein ROT1
MWSKKFTLKK LILGGYLFAQ KVYCEDESNS IYGTWSSKSN QVFTGPGFYD PVDELLIEPS LPGLSYSFTE DGWYEEATYQ VSGNPRNPTC PMASLIYQHG TYNISENGTL VLNPIEVDGR QLFSDPCNDD GVSTYSRYNQ TETFKEYAVG IDPYHGIYTL QLYQYDGTPM QPLYLAYRPP MMLPTETLNP TSSATSTDDP SSNKKRSLRS LVRRSLENRH KTNAIKRQNT SFLTSNAIWY ISAGMLGVGS LLFLAF