ROR1_HUMAN » Tyrosine-protein kinase transmembrane receptor ROR1

ROR1_HUMAN » Tyrosine-protein kinase transmembrane receptor ROR1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ROR1_HUMAN » Tyrosine-protein kinase transmembrane receptor ROR1 » Neurotrophic tyrosine kinase, receptor-related 1;
Hydrophobic Thickness 40.0 ± 4.4 Å
Tilt Angle 14 ± 0°
ΔGtransfer -29.0 kcal/mol
ΔGfold -19.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 401-428 (401-432)
Pathways none
PDB none
OPM none
Complexes none
Interactions

A4, Complex: ROR1:A4, PubMed

EGFR, Complex: EGFR:ROR1, PubMed

ERBB3, Complex: ERBB3:ROR1, PubMed

Domains

AA: 58-148, PDBID: 2EDJ, Subunit A, Seq Identity:30%, Immunoglobulin I-set domain

AA: 170-290, PDBID: 3HKL, Subunit B, Seq Identity:23%, Fz domain

AA: 313-391, PDBID: 1B2I, Subunit A, Seq Identity:46%, Kringle domain

AA: 473-746, PDBID: 3ZZW, Subunit A, Seq Identity:57%, Protein tyrosine kinase

UniProt annotation for ROR1_HUMAN » Tyrosine-protein kinase transmembrane receptor ROR1
FUNCTION: Tyrosine-protein kinase receptor whose role is not yet clear.

CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

TISSUE SPECIFICITY: Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

DEVELOPMENTAL STAGE: Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.

UniProt features for ROR1_HUMAN » Tyrosine-protein kinase transmembrane receptor ROR1
SIGNAL 1 29 Potential.
CHAIN 30 937 Tyrosine-protein kinase transmembrane receptor ROR1.
DOMAIN 42 147 Ig-like C2-type.
DOMAIN 165 299 FZ.
DOMAIN 312 391 Kringle.
DOMAIN 473 746 Protein kinase.
ACT_SITE 615 615 Proton acceptor (By similarity).
DISULFID 79 131 By similarity.
DISULFID 170 235 By similarity.
DISULFID 178 228 By similarity.
DISULFID 219 260 By similarity.
DISULFID 248 296 By similarity.
DISULFID 252 282 By similarity.
DISULFID 313 391 By similarity.
DISULFID 334 374 By similarity.
DISULFID 362 386 By similarity.
Amino Acid Sequence for ROR1_HUMAN » Tyrosine-protein kinase transmembrane receptor ROR1
MHRPRRRGTR PPLLALLAAL LLAARGAAAQ ETELSVSAEL VPTSSWNISS ELNKDSYLTL DEPMNNITTS LGQTAELHCK VSGNPPPTIR WFKNDAPVVQ EPRRLSFRST IYGSRLRIRN LDTTDTGYFQ CVATNGKEVV SSTGVLFVKF GPPPTASPGY SDEYEEDGFC QPYRGIACAR FIGNRTVYME SLHMQGEIEN QITAAFTMIG TSSHLSDKCS QFAIPSLCHY AFPYCDETSS VPKPRDLCRD ECEILENVLC QTEYIFARSN PMILMRLKLP NCEDLPQPES PEAANCIRIG IPMADPINKN HKCYNSTGVD YRGTVSVTKS GRQCQPWNSQ YPHTHTFTAL RFPELNGGHS YCRNPGNQKE APWCFTLDEN FKSDLCDIPA CDSKDSKEKN KMEILYILVP SVAIPLAIAL LFFFICVCRN NQKSSSAPVQ RQPKHVRGQN VEMSMLNAYK PKSKAKELPL SAVRFMEELG ECAFGKIYKG HLYLPGMDHA QLVAIKTLKD YNNPQQWTEF QQEASLMAEL HHPNIVCLLG AVTQEQPVCM LFEYINQGDL HEFLIMRSPH SDVGCSSDED GTVKSSLDHG DFLHIAIQIA AGMEYLSSHF FVHKDLAARN ILIGEQLHVK ISDLGLSREI YSADYYRVQS KSLLPIRWMP PEAIMYGKFS SDSDIWSFGV VLWEIFSFGL QPYYGFSNQE VIEMVRKRQL LPCSEDCPPR MYSLMTECWN EIPSRRPRFK DIHVRLRSWE GLSSHTSSTT PSGGNATTQT TSLSASPVSN LSNPRYPNYM FPSQGITPQG QIAGFIGPPI PQNQRFIPIN GYPIPPGYAA FPAAHYQPTG PPRVIQHCPP PKSRSPSSAS GSTSTGHVTS LPSSGSNQEA NIPLLPHMSI PNHPGGMGIT VFGNKSQKPY KIDSKQASLL GDANIHGHTE SMISAEL