RODZ_ECOLI » Cytoskeleton protein RodZ

RODZ_ECOLI » Cytoskeleton protein RodZ
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Topology in Bacterial Gram-negative inner membrane
Topologyextracellular side
cytoplasmic side
RODZ_ECOLI » Cytoskeleton protein RodZ »
Hydrophobic Thickness 27.8 ± 3.5 Å
Tilt Angle 26 ± 0°
ΔGtransfer -23.3 kcal/mol
ΔGfold -17.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 112-133 (109-138)
Pathways none
PDB none
OPM none
Complexes none
Interactions

MREC, Complex: MREC:RODZ

Domains

AA: 19-57, PDBID: 2PPX, Subunit A, Seq Identity:45%, Helix-turn-helix

AA: 255-329, Domain of unknown function (DUF4115)

UniProt annotation for RODZ_ECOLI » Cytoskeleton protein RodZ
FUNCTION: Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis.

DOMAIN: The helix-turn-helix (HTH) motif in the cytoplasmic domain of the N-terminus is involved in the formation of spirals to maintain the rigid rod shape. As this protein is anchored in the cytoplasmic membrane, the HTH motif may contribute to protein- protein interactions to form the RodZ helix, which is localized beneath the cytoplasmic membrane. The C-terminal domain may be critical for determination of the rod shape by probably interacting with enzymes required for synthesis of the peptidoglycan layer, including PBPs in the periplasm.

UniProt features for RODZ_ECOLI » Cytoskeleton protein RodZ
CHAIN 1 337 Cytoskeleton protein RodZ.
DOMAIN 19 71 HTH cro/C1-type.
DNA_BIND 30 49 H-T-H motif (By similarity).
Amino Acid Sequence for RODZ_ECOLI » Cytoskeleton protein RodZ
MNTEATHDQN EALTTGARLR NAREQLGLSQ QAVAERLCLK VSTVRDIEED KAPADLASTF LRGYIRSYAR LVHIPEEELL PGLEKQAPLR AAKVAPMQSF SLGKRRKKRD GWLMTFTWLV LFVVIGLSGA WWWQDRKAQQ EEITTMADQS SAELSSNSEQ GQSVPLNTST TTDPATTSTP PASVDTTATN TQTPAVTAPA PAVDPQQNAV VSPSQANVDT AATPAPTAAT TPDGAAPLPT DQAGVTTPVA DPNALVMNFT ADCWLEVTDA TGKKLFSGMQ RKDGNLNLTG QAPYKLKIGA PAAVQIQYQG KPVDLSRFIR TNQVARLTLN AEQSPAQ