ROBO4_HUMAN » Roundabout homolog 4

ROBO4_HUMAN » Roundabout homolog 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ROBO4_HUMAN » Roundabout homolog 4 » Magic roundabout;
Hydrophobic Thickness 34.6 ± 1.1 Å
Tilt Angle 2 ± 4°
ΔGtransfer -17.4 kcal/mol
ΔGfold -14.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 468-490 (468-495)
Pathways none
PDB none
OPM none
Complexes none
Interactions

ROBO1, Complex: ROBO1:ROBO4, PubMed

VGFR1, Complex: ROBO4:VGFR1, PubMed

Domains

AA: 31-118, PDBID: 2V9Q, Subunit A, Seq Identity:33%, Immunoglobulin domain

AA: 137-224, PDBID: 2V9Q, Subunit A, Seq Identity:46%, Immunoglobulin I-set domain

AA: 348-432, PDBID: 4HLJ, Subunit A, Seq Identity:38%, Fibronectin type III domain

UniProt annotation for ROBO4_HUMAN » Roundabout homolog 4
FUNCTION: Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

SUBUNIT: Interacts with SLIT2 and ENAH.

TISSUE SPECIFICITY: Specifically expressed in endothelial cells. Expressed at sites of angiogenesis in different tumor types.

UniProt features for ROBO4_HUMAN » Roundabout homolog 4
SIGNAL 1 27 Potential.
CHAIN 28 1007 Roundabout homolog 4.
DOMAIN 32 131 Ig-like C2-type 1.
DOMAIN 137 224 Ig-like C2-type 2.
DOMAIN 252 340 Fibronectin type-III 1.
DOMAIN 347 438 Fibronectin type-III 2.
DISULFID 53 114 Potential.
DISULFID 158 207 Potential.
Amino Acid Sequence for ROBO4_HUMAN » Roundabout homolog 4
MGSGGDSLLG GRGSLPLLLL LIMGGMAQDS PPQILVHPQD QLFQGPGPAR MSCQASGQPP PTIRWLLNGQ PLSMVPPDPH HLLPDGTLLL LQPPARGHAH DGQALSTDLG VYTCEASNRL GTAVSRGARL SVAVLREDFQ IQPRDMVAVV GEQFTLECGP PWGHPEPTVS WWKDGKPLAL QPGRHTVSGG SLLMARAEKS DEGTYMCVAT NSAGHRESRA ARVSIQEPQD YTEPVELLAV RIQLENVTLL NPDPAEGPKP RPAVWLSWKV SGPAAPAQSY TALFRTQTAP GGQGAPWAEE LLAGWQSAEL GGLHWGQDYE FKVRPSSGRA RGPDSNVLLL RLPEKVPSAP PQEVTLKPGN GTVFVSWVPP PAENHNGIIR GYQVWSLGNT SLPPANWTVV GEQTQLEIAT HMPGSYCVQV AAVTGAGAGE PSRPVCLLLE QAMERATQEP SEHGPWTLEQ LRATLKRPEV IATCGVALWL LLLGTAVCIH RRRRARVHLG PGLYRYTSED AILKHRMDHS DSQWLADTWR STSGSRDLSS SSSLSSRLGA DARDPLDCRR SLLSWDSRSP GVPLLPDTST FYGSLIAELP SSTPARPSPQ VPAVRRLPPQ LAQLSSPCSS SDSLCSRRGL SSPRLSLAPA EAWKAKKKQE LQHANSSPLL RGSHSLELRA CELGNRGSKN LSQSPGAVPQ ALVAWRALGP KLLSSSNELV TRHLPPAPLF PHETPPTQSQ QTQPPVAPQA PSSILLPAAP IPILSPCSPP SPQASSLSGP SPASSRLSSS SLSSLGEDQD SVLTPEEVAL CLELSEGEET PRNSVSPMPR APSPPTTYGY ISVPTASEFT DMGRTGGGVG PKGGVLLCPP RPCLTPTPSE GSLANGWGSA SEDNAASARA SLVSSSDGSF LADAHFARAL AVAVDSFGFG LEPREADCVF IDASSPPSPR DEIFLTPNLS LPLWEWRPDW LEDMEVSHTQ RLGRGMPPWP PDSQISSQRS QLHCRMPKAG ASPVDYS