ROBO2_HUMAN » Roundabout homolog 2

ROBO2_HUMAN » Roundabout homolog 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
ROBO2_HUMAN » Roundabout homolog 2 »
Hydrophobic Thickness 31.2 ± 2.8 Å
Tilt Angle 1 ± 0°
ΔGtransfer -31.7 kcal/mol
ΔGfold -13.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 860-882 (859-887)
Pathways

Axon guidance (KEGG)

Developmental Biology (Reactome)

PDB 2edj (417-509), 1uem (514-617), 1ujt (628-734)
OPM none
Complexes none
Interactions

BNI3L, Complex: BNI3L:ROBO2, PubMed

DCC, Complex: ROBO2:DCC, PubMed

DPB1, Complex: ROBO2:DPB1, PubMed

RDH11, Complex: RDH11:ROBO2, PubMed

ROBO1, Complex: ROBO1:ROBO2, PubMed

TRI13, Complex: ROBO2:TRI13, PubMed

Domains

AA: 30-114, PDBID: 2V9Q, Subunit A, Seq Identity:93%, Immunoglobulin domain

AA: 134-207, PDBID: 1CS6, Subunit A, Seq Identity:34%, Immunoglobulin domain

AA: 225-310, PDBID: 2V9Q, Subunit A, Seq Identity:54%, Immunoglobulin I-set domain

AA: 313-394, PDBID: 3DMK, Subunit A, Seq Identity:30%, Immunoglobulin domain

AA: 418-505, PDBID: 2EDJ, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 523-607, PDBID: 1UEM, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 640-724, PDBID: 1UJT, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 738-826, PDBID: 4HLJ, Subunit A, Seq Identity:61%, Fibronectin type III domain

UniProt annotation for ROBO2_HUMAN » Roundabout homolog 2
FUNCTION: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.

SUBUNIT: Interacts with SLIT2.

DISEASE: Vesicoureteral reflux 2 (VUR2) OMIM: A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease. mutations affecting the gene represented in this entry.

DISEASE: Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT- ROBO signaling in vitro.

UniProt features for ROBO2_HUMAN » Roundabout homolog 2
SIGNAL 1 21 Potential.
CHAIN 22 1378 Roundabout homolog 2.
DOMAIN 31 127 Ig-like C2-type 1.
DOMAIN 133 220 Ig-like C2-type 2.
DOMAIN 225 309 Ig-like C2-type 3.
DOMAIN 314 409 Ig-like C2-type 4.
DOMAIN 418 504 Ig-like C2-type 5.
DOMAIN 522 607 Fibronectin type-III 1.
DOMAIN 634 724 Fibronectin type-III 2.
DOMAIN 736 826 Fibronectin type-III 3.
DISULFID 52 110 Potential.
DISULFID 154 203 Potential.
DISULFID 246 293 Potential.
DISULFID 335 391 Potential.
DISULFID 439 488 Potential.
Amino Acid Sequence for ROBO2_HUMAN » Roundabout homolog 2
MSLLMFTQLL LCGFLYVRVD GSRLRQEDFP PRIVEHPSDV IVSKGEPTTL NCKAEGRPTP TIEWYKDGER VETDKDDPRS HRMLLPSGSL FFLRIVHGRR SKPDEGSYVC VARNYLGEAV SRNASLEVAL LRDDFRQNPT DVVVAAGEPA ILECQPPRGH PEPTIYWKKD KVRIDDKEER ISIRGGKLMI SNTRKSDAGM YTCVGTNMVG ERDSDPAELT VFERPTFLRR PINQVVLEEE AVEFRCQVQG DPQPTVRWKK DDADLPRGRY DIKDDYTLRI KKTMSTDEGT YMCIAENRVG KMEASATLTV RAPPQFVVRP RDQIVAQGRT VTFPCETKGN PQPAVFWQKE GSQNLLFPNQ PQQPNSRCSV SPTGDLTITN IQRSDAGYYI CQALTVAGSI LAKAQLEVTD VLTDRPPPII LQGPANQTLA VDGTALLKCK ATGDPLPVIS WLKEGFTFPG RDPRATIQEQ GTLQIKNLRI SDTGTYTCVA TSSSGETSWS AVLDVTESGA TISKNYDLSD LPGPPSKPQV TDVTKNSVTL SWQPGTPGTL PASAYIIEAF SQSVSNSWQT VANHVKTTLY TVRGLRPNTI YLFMVRAINP QGLSDPSPMS DPVRTQDISP PAQGVDHRQV QKELGDVLVR LHNPVVLTPT TVQVTWTVDR QPQFIQGYRV MYRQTSGLQA TSSWQNLDAK VPTERSAVLV NLKKGVTYEI KVRPYFNEFQ GMDSESKTVR TTEEAPSAPP QSVTVLTVGS YNSTSISVSW DPPPPDHQNG IIQEYKIWCL GNETRFHINK TVDAAIRSVI IGGLFPGIQY RVEVAASTSA GVGVKSEPQP IIIGRRNEVV ITENNNSITE QITDVVKQPA FIAGIGGACW VILMGFSIWL YWRRKKRKGL SNYAVTFQRG DGGLMSNGSR PGLLNAGDPS YPWLADSWPA TSLPVNNSNS GPNEIGNFGR GDVLPPVPGQ GDKTATMLSD GAIYSSIDFT TKTSYNSSSQ ITQATPYATT QILHSNSIHE LAVDLPDPQW KSSIQQKTDL MGFGYSLPDQ NKGNNGGKGG KKKKNKNSSK PQKNNGSTWA NVPLPPPPVQ PLPGTELEHY AVEQQENGYD SDSWCPPLPV QTYLHQGLED ELEEDDDRVP TPPVRGVASS PAISFGQQST ATLTPSPREE MQPMLQAHLD ELTRAYQFDI AKQTWHIQSN NQPPQPPVPP LGYVSGALIS DLETDVADDD ADDEEEALEI PRPLRALDQT PGSSMDNLDS SVTGKAFTSS QRPRPTSPFS TDSNTSAALS QSQRPRPTKK HKGGRMDQQP ALPHRREGMT DEEALVPYSK PSFPSPGGHS SSGTASSKGS TGPRKTEVLR AGHQRNASDL LDIGYMGSNS QGQFTGEL