RMD3_HUMAN » Regulator of microtubule dynamics protein 3

RMD3_HUMAN » Regulator of microtubule dynamics protein 3
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Topology in Mitochondrial outer membrane
Topologyintermembrane space
cytoplasmic side
RMD3_HUMAN » Regulator of microtubule dynamics protein 3 » RMD-3; hRMD-3; Cerebral protein 10;Protein FAM82A2;Protein FAM82C;Protein tyrosine phosphatase-interacting protein 51;TCPTP-interacting protein 51;
Hydrophobic Thickness 26.8 ± 3.6 Å
Tilt Angle 0 ± 2°
ΔGtransfer -25.3 kcal/mol
ΔGfold -9.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 12-32 (9-33)
Pathways none
PDB none
OPM none
Complexes none
Interactions

F162A, Complex: RMD3:F162A, PubMed

VAPA, Complex: RMD3:VAPA, PubMed

Domains none
UniProt annotation for RMD3_HUMAN » Regulator of microtubule dynamics protein 3
FUNCTION: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis.

SUBUNIT: Interacts with PTPN2. Interacts with microtubules. Interacts with VAPB.

TISSUE SPECIFICITY: Present at high level in epidermis and seminiferous epithelium: while basal cells in the epidermis and spermatogonia show no perceptible amount, keratinocytes of suprabasal layers and differentiating first-order spermatocytes up to spermatids exhibit high expression. In skeletal muscle, its presence is restricted to fibers of the fast twitch type. In surface epithelia containing ciliated cells, it is associated with the microtubular structures responsible for ciliary movement. Also present in specific structures of the central nervous system such as neurons of the hippocampal region, ganglion cells of the autonomic nervous system, and axons of the peripheral nervous system (at protein level). Widely expressed.

INDUCTION: By EGF, TGFB1, retinoic acid-and 1,25-dihydroxyvitamin D(3).

DOMAIN: The transmembrane region is required for mitochondrial localization.

UniProt features for RMD3_HUMAN » Regulator of microtubule dynamics protein 3
CHAIN 1 470 Regulator of microtubule dynamics protein 3.
COILED 92 124 Potential.
Amino Acid Sequence for RMD3_HUMAN » Regulator of microtubule dynamics protein 3
MSRLGALGGA RAGLGLLLGT AAGLGFLCLL YSQRWKRTQR HGRSQSLPNS LDYTQTSDPG RHVMLLRAVP GGAGDASVLP SLPREGQEKV LDRLDFVLTS LVALRREVEE LRSSLRGLAG EIVGEVRCHM EENQRVARRR RFPFVRERSD STGSSSVYFT ASSGATFTDA ESEGGYTTAN AESDNERDSD KESEDGEDEV SCETVKMGRK DSLDLEEEAA SGASSALEAG GSSGLEDVLP LLQQADELHR GDEQGKREGF QLLLNNKLVY GSRQDFLWRL ARAYSDMCEL TEEVSEKKSY ALDGKEEAEA ALEKGDESAD CHLWYAVLCG QLAEHESIQR RIQSGFSFKE HVDKAIALQP ENPMAHFLLG RWCYQVSHLS WLEKKTATAL LESPLSATVE DALQSFLKAE ELQPGFSKAG RVYISKCYRE LGKNSEARWW MKLALELPDV TKEDLAIQKD LEELEVILRD