RIC3_HUMAN » Protein RIC-3

RIC3_HUMAN » Protein RIC-3
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
RIC3_HUMAN » Protein RIC-3 »
Hydrophobic Thickness 31.2 ± 4.2 Å
Tilt Angle 17 ± 10°
ΔGtransfer -16.0 kcal/mol
ΔGfold -10.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 95-117 (95-122)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 15-166, Resistance to inhibitors of cholinesterase homologue 3

UniProt annotation for RIC3_HUMAN » Protein RIC-3
FUNCTION: Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.

SUBUNIT: Monomer and homodimer. Interacts with CHRNA7, CHRNA3, CHRNA4, CHRNB2, CHRNB4 and HTR3A.

TISSUE SPECIFICITY: Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland. Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain.

DOMAIN: The coiled-coil domain mediates transient homodimerization with other acetylcholine receptor-bound RIC3 molecules, promoting stepwise ACHR homomeric assembly at the membrane.

UniProt features for RIC3_HUMAN » Protein RIC-3
SIGNAL 1 28 Potential.
CHAIN 29 369 Protein RIC-3.
COILED 140 169 Potential.
CROSSLNK 202 202 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate.
Amino Acid Sequence for RIC3_HUMAN » Protein RIC-3
MAYSTVQRVA LASGLVLALS LLLPKAFLSR GKRQEPPPTP EGKLGRFPPM MHHHQAPSDG QTPGARFQRS HLAEAFAKAK GSGGGAGGGG SGRGLMGQII PIYGFGIFLY ILYILFKLSK GKTTAEDGKC YTAMPGNTHR KITSFELAQL QEKLKETEAA MEKLINRVGP NGESRAQTVT SDQEKRLLHQ LREITRVMKE GKFIDRFSPE KEAEEAPYME DWEGYPEETY PIYDLSDCIK RRQETILVDY PDPKELSAEE IAERMGMIEE EESDHLGWES LPTDPRAQED NSVTSCDPKP ETCSCCFHED EDPAVLAENA GFSADSYPEQ EETTKEEWSQ DFKDEGLGIS TDKAYTGSML RKRNPQGLE