RIC1_HUMAN » Protein RIC1 homolog

RIC1_HUMAN » Protein RIC1 homolog
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Topology in Golgi apparatus membrane
TopologyGolgi lumenal side
cytoplasmic side
RIC1_HUMAN » Protein RIC1 homolog » Connexin-43-interacting protein of 150 kDa;
Hydrophobic Thickness 27.2 ± 1.4 Å
Tilt Angle 45 ± 2°
ΔGtransfer -16.7 kcal/mol
ΔGfold -8.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 1267-1287 (1267-1287)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CD3Z, Complex: CD3Z:RIC1, PubMed

Domains

AA: 733-992, RIC1

UniProt annotation for RIC1_HUMAN » Protein RIC1 homolog
FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1- RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1.

SUBUNIT: Forms a complex with RGP1; the interaction enhances RAB6A GTPase activity. Interacts (via central domain) with RGP1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts (via C-terminus domain) with RAB33B; the interaction is direct with a preference for RAB33B-GTP. Interacts with GJA1.

TISSUE SPECIFICITY: Present in kidney and various cell lines (at protein level). Widely expressed at low level.

UniProt features for RIC1_HUMAN » Protein RIC1 homolog
CHAIN 1 1423 Protein RIC1 homolog.
REPEAT 64 103 WD 1.
REPEAT 304 343 WD 2.
Amino Acid Sequence for RIC1_HUMAN » Protein RIC1 homolog
MYFLSGWPKR LLCPLGSPAE APFHVQSDPQ RAFFAVLAAA RLSIWYSRPS VLIVTYKEPA KSSTQFGSYK QAEWRPDSTM IAVSTANGYI LFFHITSTRG DKYLYEPVYP KGSPQMKGTP HFKEEQCAPA LNLEMRKILD LQAPIMSLQS VLEDLLVATS DGLLHLIHWE GMTNGRKAIN LCTVPFSVDL QSSRVGSFLG FTDVHIRDME YCATLDGFAV VFNDGKVGFI TPVSSRFTAE QLHGVWPQDV VDGTCVAVNN KYRLMAFGCV SGSVQVYTID NSTGAMLLSH KLELTAKQYP DIWNKTGAVK LMRWSPDNSV VIVTWEYGGL SLWSVFGAQL ICTLGGDFAY RSDGTKKDPL KINSMSWGAE GYHLWVISGF GSQNTEIESD LRSVVKQPSI LLFQFIKSVL TVNPCMSNQE QVLLQGEDRL YLNCGEASQT QNPRSSSTHS EHKPSREKSP FADGGLESQG LSTLLGHRHW HVVQISSTYL ESNWPIRFSA IDKLGQNIAV VGKFGFAHYS LLTKKWKLFG NITQEQNMIV TGGLAWWNDF MVLACYNIND RQEELRVYLR TSNLDNAFAH VTKAQAETLL LSVFQDMVIV FRADCSICLY SIERKSDGPN TTAGIQVLQE VSMSRYIPHP FLVVSVTLTS VSTENGITLK MPQQARGAES IMLNLAGQLI MMQRDRSGPQ IREKDSNPNN QRKLLPFCPP VVLAQSVENV WTTCRANKQK RHLLEALWLS CGGAGMKVWL PLFPRDHRKP HSFLSQRIML PFHINIYPLA VLFEDALVLG AVNDTLLYDS LYTRNNAREQ LEVLFPFCVV ERTSQIYLHH ILRQLLVRNL GEQALLLAQS CATLPYFPHV LELMLHEVLE EEATSREPIP DPLLPTVAKF ITEFPLFLQT VVHCARKTEY ALWNYLFAAV GNPKDLFEEC LMAQDLDTAA SYLIILQNME VPAVSRQHAT LLFNTALEQG KWDLCRHMIR FLKAIGSGES ETPPSTPTAQ EPSSSGGFEF FRNRSISLSQ SAENVPASKF SLQKTLSMPS GPSGKRWSKD SDCAENMYID MMLWRHARRL LEDVRLKDLG CFAAQLGFEL ISWLCKERTR AARVDNFVIA LKRLHKDFLW PLPIIPASSI SSPFKNGKYR TVGEQLLKSQ SADPFLNLEM DAGISNIQRS QSWLSNIGPT HHEIDTASSH GPQMQDAFLS PLSNKGDECS IGSATDLTES SSMVDGDWTM VDENFSTLSL TQSELEHISM ELASKGPHKS QVQLRYLLHI FMEAGCLDWC IVIGLILRES SIINQILVIT QSSEVDGEML QNIKTGLHAV DRWASTDCPG YKPFLNIIKP QLQKLSEITE EQVQPDAFQP ITMGKTPEQT SPRAEESRGS SSHGSIPQGE VGSSNMVSRK EEDTAQAEEE EPFQDGTYDC SVS