RET1G_HUMAN » Retinoic acid early transcript 1G protein

RET1G_HUMAN » Retinoic acid early transcript 1G protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
RET1G_HUMAN » Retinoic acid early transcript 1G protein »
Hydrophobic Thickness 33.2 ± 2.5 Å
Tilt Angle 1 ± 5°
ΔGtransfer -20.1 kcal/mol
ΔGfold -13.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 223-244 (220-245)
Pathways

Natural killer cell mediated cytotoxicity (KEGG)

PDB none
OPM none
Complexes none
Interactions

NKG2D, Complex: NKG2D:RET1G, PubMed

NKG2F, Complex: NKG2F:RET1G, PubMed

Domains

AA: 29-205, PDBID: 1KCG, Subunit C, Seq Identity:49%, Class I Histocompatibility antigen, domains alpha 1 and 2

UniProt annotation for RET1G_HUMAN » Retinoic acid early transcript 1G protein
FUNCTION: Acts as a ligand for the KLRK1 receptor and mediates NK cell cytotoxicity via the receptor.

SUBUNIT: Binds to KLRK1/NKG2D. Also binds the CMV glycoprotein UL16.

TISSUE SPECIFICITY: Isoform 1 is highly expressed in colon and in a number of tumor cell lines and highly restricted in normal tissues. Both isoforms are frequently expressed in cell lines derived from epithelial cancers, and in primary breast cancers.

UniProt features for RET1G_HUMAN » Retinoic acid early transcript 1G protein
SIGNAL 1 25 By similarity.
CHAIN 26 334 Retinoic acid early transcript 1G protein.
REGION 29 117 MHC class I alpha-1 like.
REGION 118 210 MHC class I alpha-2 like.
DISULFID 50 66 By similarity.
DISULFID 127 190 By similarity.
Amino Acid Sequence for RET1G_HUMAN » Retinoic acid early transcript 1G protein
MAAAASPAFL LRLPLLLLLS SWCRTGLADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT FLHYDCGSKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLLDIQL ENYIPKEPLT LQARMSCEQK AEGHGSGSWQ LSFDGQIFLL FDSENRMWTT VHPGARKMKE KWENDKDMTM SFHYISMGDC TGWLEDFLMG MDSTLEPSAG APPTMSSGTA QPRATATTLI LCCLLIMCLL ICSRHSLTQS HGHHPQSLQP PPHPPLLHPT WLLRRVLWSD SYQIAKRPLS GGHVTRVTLP IIGDDSHSLP CPLALYTINN GAARYSEPLQ VSIS