RENR_HUMAN » Renin receptor

RENR_HUMAN » Renin receptor
Magnify RENR_HUMAN » Renin receptorEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
RENR_HUMAN » Renin receptor » ATPase H(+)-transporting lysosomal accessory protein 2;ATPase H(+)-transporting lysosomal-interacting protein 2;ER-localized type I transmembrane adaptor;Embryonic liver differentiation factor 10;N14F;Renin/prorenin receptor;Vacuolar ATP synthase membrane
Hydrophobic Thickness 34.8 ± 2.4 Å
Tilt Angle 0 ± 4°
ΔGtransfer -39.7 kcal/mol
ΔGfold -21.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 301-326 (301-326)
Pathways none
PDB 3lbs (A/B=333-350), 3lc8 (A/B=333-350)
OPM none
Complexes none
Interactions none
Domains

AA: 254-350, PDBID: 3LBS, Subunit A, Seq Identity:100%, Renin receptor-like protein

UniProt annotation for RENR_HUMAN » Renin receptor
FUNCTION: Functions as a renin and prorenin cellular receptor. May mediate renin-dependent cellular responses by activating ERK1 and ERK2. By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, it may also play a role in the renin-angiotensin system (RAS).

SUBUNIT: Interacts with renin and the vacuolar proton-ATPase.

TISSUE SPECIFICITY: Expressed in brain, heart, placenta, liver, kidney and pancreas. Barely detectable in lung and skeletal muscles. In the kidney cortex it is restricted to the mesangium of glomeruli. In the coronary and kidney artery it is expressed in the subendothelium, associated to smooth muscles where it colocalizes with REN. Expressed in vascular structures and by syncytiotrophoblast cells in the mature fetal placenta.

DISEASE: Mental retardation, X-linked, with epilepsy (MRXE) OMIM: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRXE patients manifest mild to moderate mental retardation associated with epilepsy, delays in motor milestones and speech acquisition in infancy. mutations affecting the gene represented in this entry.

DISEASE: Parkinsonism with spasticity, X-linked (XPDS) OMIM: A syndrome characterized by parkinsonian features, such as cogwheel rigidity, resting tremor and bradykinesia, and variably penetrant spasticity. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for RENR_HUMAN » Renin receptor
SIGNAL 1 16 Potential.
CHAIN 17 350 Renin receptor.
Amino Acid Sequence for RENR_HUMAN » Renin receptor
MAVFVVLLAL VAGVLGNEFS ILKSPGSVVF RNGNWPIPGE RIPDVAALSM GFSVKEDLSW PGLAVGNLFH RPRATVMVMV KGVNKLALPP GSVISYPLEN AVPFSLDSVA NSIHSLFSEE TPVVLQLAPS EERVYMVGKA NSVFEDLSVT LRQLRNRLFQ ENSVLSSLPL NSLSRNNEVD LLFLSELQVL HDISSLLSRH KHLAKDHSPD LYSLELAGLD EIGKRYGEDS EQFRDASKIL VDALQKFADD MYSLYGGNAV VELVTVKSFD TSLIRKTRTI LEAKQAKNPA SPYNLAYKYN FEYSVVFNMV LWIMIALALA VIITSYNIWN MDPGYDSIIY RMTNQKIRMD