![]() | extracellular side |
cytoplasmic side |
RAMP3_HUMAN » Receptor activity-modifying protein 3 » Calcitonin-receptor-like receptor activity-modifying protein 3;CRLR activity-modifying protein 3; | |
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Hydrophobic Thickness | 36.0 ± 4.2 Å |
Tilt Angle | 20 ± 5° |
ΔGtransfer | -29.3 kcal/mol |
ΔGfold | -16.7 kcal/mol |
Links | UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC |
Topology | Out |
TM Segments | 115-139 (115-143) |
Pathways | Signal Transduction (Reactome) |
PDB | none |
OPM | none |
Complexes | none |
Interactions | |
Domains | AA: 37-146, PDBID: 2YX8, Subunit A, Seq Identity:35%, Receptor activity modifying family |
UniProt annotation for RAMP3_HUMAN » Receptor activity-modifying protein 3 |
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FUNCTION: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. SUBUNIT: Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1. TISSUE SPECIFICITY: Strongly expressed in lung, breast, immune system and fetal tissues. |
UniProt features for RAMP3_HUMAN » Receptor activity-modifying protein 3 |
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SIGNAL 1 23 Potential. CHAIN 24 148 Receptor activity-modifying protein 3. DISULFID 40 72 By similarity. DISULFID 57 104 By similarity. |
Amino Acid Sequence for RAMP3_HUMAN » Receptor activity-modifying protein 3 |
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METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEVLI PLIVIPVVLT VAMAGLVVWR SKRTDTLL |