RAMP3_HUMAN » Receptor activity-modifying protein 3

RAMP3_HUMAN » Receptor activity-modifying protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
RAMP3_HUMAN » Receptor activity-modifying protein 3 » Calcitonin-receptor-like receptor activity-modifying protein 3;CRLR activity-modifying protein 3;
Hydrophobic Thickness 36.0 ± 4.2 Å
Tilt Angle 20 ± 5°
ΔGtransfer -29.3 kcal/mol
ΔGfold -16.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 115-139 (115-143)
Pathways

Signal Transduction (Reactome)

Vascular smooth muscle contraction (KEGG)
PDB none
OPM none
Complexes none
Interactions

RAMP2, Complex: RAMP3:RAMP2:ADML, PubMed
Domains

AA: 37-146, PDBID: 2YX8, Subunit A, Seq Identity:35%, Receptor activity modifying family
UniProt annotation for RAMP3_HUMAN » Receptor activity-modifying protein 3
FUNCTION: Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

SUBUNIT: Heterodimer of CALCRL and RAMP3 (By similarity). Interacts with GPER1.

TISSUE SPECIFICITY: Strongly expressed in lung, breast, immune system and fetal tissues.

UniProt features for RAMP3_HUMAN » Receptor activity-modifying protein 3
SIGNAL 1 23 Potential.
CHAIN 24 148 Receptor activity-modifying protein 3.
DISULFID 40 72 By similarity.
DISULFID 57 104 By similarity.
Amino Acid Sequence for RAMP3_HUMAN » Receptor activity-modifying protein 3
METGALRRPQ LLPLLLLLCG GCPRAGGCNE TGMLERLPLC GKAFADMMGK VDVWKWCNLS EFIVYYESFT NCTEMEANVV GCYWPNPLAQ GFITGIHRQF FSNCTVDRVH LEDPPDEVLI PLIVIPVVLT VAMAGLVVWR SKRTDTLL