RAMP2_HUMAN » Receptor activity-modifying protein 2

RAMP2_HUMAN » Receptor activity-modifying protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
RAMP2_HUMAN » Receptor activity-modifying protein 2 » Calcitonin-receptor-like receptor activity-modifying protein 2;CRLR activity-modifying protein 2;
Hydrophobic Thickness 36.8 ± 2.8 Å
Tilt Angle 4 ± 5°
ΔGtransfer -27.0 kcal/mol
ΔGfold -17.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 143-167 (143-169)
Pathways

Signal Transduction (Reactome)

Vascular smooth muscle contraction (KEGG)

PDB 2xvt (A/B...=48-139), 3aqe (A/B...=56-139), 3aqf (A=56-139)
OPM none
Complexes none
Interactions

RAMP1, Complex: RAMP1:RPC9:RAMP2, PubMed

RAMP3, Complex: RAMP3:RAMP2:ADML, PubMed

Domains

AA: 65-173, PDBID: 2XVT, Subunit A, Seq Identity:100%, Receptor activity modifying family

UniProt annotation for RAMP2_HUMAN » Receptor activity-modifying protein 2
FUNCTION: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL.

SUBUNIT: Heterodimer of CALCRL and RAMP2.

TISSUE SPECIFICITY: Strongly expressed in lung, breast, immune system and fetal tissues.

UniProt features for RAMP2_HUMAN » Receptor activity-modifying protein 2
SIGNAL 1 42 Potential.
CHAIN 43 175 Receptor activity-modifying protein 2.
DISULFID 68 99
DISULFID 84 131
Amino Acid Sequence for RAMP2_HUMAN » Receptor activity-modifying protein 2
MASLRVERAG GPRLPRTRVG RPAALRLLLL LGAVLNPHEA LAQPLPTTGT PGSEGGTVKN YETAVQFCWN HYKDQMDPIE KDWCDWAMIS RPYSTLRDCL EHFAELFDLG FPNPLAERII FETHQIHFAN CSLVQPTFSD PPEDVLLAMI IAPICLIPFL ITLVVWRSKD SEAQA