RAMP1_HUMAN » Receptor activity-modifying protein 1

RAMP1_HUMAN » Receptor activity-modifying protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
RAMP1_HUMAN » Receptor activity-modifying protein 1 » Calcitonin-receptor-like receptor activity-modifying protein 1;CRLR activity-modifying protein 1;
Hydrophobic Thickness 33.2 ± 2.4 Å
Tilt Angle 6 ± 7°
ΔGtransfer -20.4 kcal/mol
ΔGfold -15.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 119-141 (119-143)
Pathways

Signal Transduction (Reactome)

Vascular smooth muscle contraction (KEGG)

PDB 2yx8 (A=27-112), 3n7r (C/D=26-117), 3n7s (C/D=26-117), 3n7p (D/E/F/R=26-117)
OPM none
Complexes none
Interactions

RAMP2, Complex: RAMP1:RPC9:RAMP2, PubMed

Domains

AA: 37-146, PDBID: 2YX8, Subunit A, Seq Identity:100%, Receptor activity modifying family

UniProt annotation for RAMP1_HUMAN » Receptor activity-modifying protein 1
FUNCTION: Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.

SUBUNIT: Heterodimer of CALCRL and RAMP1.

TISSUE SPECIFICITY: Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.

UniProt features for RAMP1_HUMAN » Receptor activity-modifying protein 1
SIGNAL 1 26 Potential.
CHAIN 27 148 Receptor activity-modifying protein 1.
DISULFID 27 82
DISULFID 40 72
DISULFID 57 104
Amino Acid Sequence for RAMP1_HUMAN » Receptor activity-modifying protein 1
MARALCRLPR RGLWLLLAHH LFMTTACQEA NYGALLRELC LTQFQVDMEA VGETLWCDWG RTIRSYRELA DCTWHMAEKL GCFWPNAEVD RFFLAVHGRY FRSCPISGRA VRDPPGSILY PFIVVPITVT LLVTALVVWQ SKRTEGIV