RAGE_HUMAN » Advanced glycosylation end product-specific receptor

RAGE_HUMAN » Advanced glycosylation end product-specific receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
RAGE_HUMAN » Advanced glycosylation end product-specific receptor » Receptor for advanced glycosylation end products;
Hydrophobic Thickness 38.0 ± 3.2 Å
Tilt Angle 0 ± 2°
ΔGtransfer -43.0 kcal/mol
ΔGfold -18.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 337-365 (335-372)
Pathways

Immune System (Reactome)

PDB 2e5e (23-121), 2mov (23-125), 3o3u (23-231), 4lp4 (23-231), 4ofv (23-235), 4oi8 (23-237), 4oi7 (23-237), 4of5 (23-237), 3cjj (23-240), 4lp5 (23-323), 2ens (235-323), 2lmb (363-376), 4n6i (54-68), 2mjw (A/C=23-121), 2le9 (A/D=235-327), 2l7u (A=23-125), 4p2y (A=23-323)
OPM none
Complexes none
Interactions

A4, Complex: RAGE:A4, PubMed

CALX, Complex: CALX:RAGE, PubMed

SC61B, Complex: SC61B:RAGE, PubMed

TLR9, Complex: TLR9:RAGE, PubMed

Domains

AA: 21-112, PDBID: 2E5E, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 124-219, PDBID: 3CJJ, Subunit A, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

AA: 237-320, PDBID: 2ENS, Subunit A, Seq Identity:100%, Immunoglobulin domain

UniProt annotation for RAGE_HUMAN » Advanced glycosylation end product-specific receptor
FUNCTION: Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF- alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

SUBUNIT: Interacts with S100A1 and APP (By similarity). Interacts with S100B, S100A12 and S100A14. Constitutive homodimer; disulfide-linked.

TISSUE SPECIFICITY: Endothelial cells.

UniProt features for RAGE_HUMAN » Advanced glycosylation end product-specific receptor
SIGNAL 1 22 Potential.
CHAIN 23 404 Advanced glycosylation end product- specific receptor.
DOMAIN 23 116 Ig-like V-type.
DOMAIN 124 221 Ig-like C2-type 1.
DOMAIN 227 317 Ig-like C2-type 2.
DISULFID 38 99 Potential.
DISULFID 144 208 Potential.
DISULFID 259 301 Potential.
Amino Acid Sequence for RAGE_HUMAN » Advanced glycosylation end product-specific receptor
MAAGTAVGAW VLVLSLWGAV VGAQNITARI GEPLVLKCKG APKKPPQRLE WKLNTGRTEA WKVLSPQGGG PWDSVARVLP NGSLFLPAVG IQDEGIFRCQ AMNRNGKETK SNYRVRVYQI PGKPEIVDSA SELTAGVPNK VGTCVSEGSY PAGTLSWHLD GKPLVPNEKG VSVKEQTRRH PETGLFTLQS ELMVTPARGG DPRPTFSCSF SPGLPRHRAL RTAPIQPRVW EPVPLEEVQL VVEPEGGAVA PGGTVTLTCE VPAQPSPQIH WMKDGVPLPL PPSPVLILPE IGPQDQGTYS CVATHSSHGP QESRAVSISI IEPGEEGPTA GSVGGSGLGT LALALGILGG LGTAALLIGV ILWQRRQRRG EERKAPENQE EEEERAELNQ SEEPEAGESS TGGP