R9BP_HUMAN » Regulator of G-protein signaling 9-binding protein

R9BP_HUMAN » Regulator of G-protein signaling 9-binding protein
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
R9BP_HUMAN » Regulator of G-protein signaling 9-binding protein » RGS9-anchoring protein;
Hydrophobic Thickness 34.4 ± 4.2 Å
Tilt Angle 29 ± 21°
ΔGtransfer -23.7 kcal/mol
ΔGfold -22.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 207-232 (206-234)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 6-104, Syntaxin-like protein

UniProt annotation for R9BP_HUMAN » Regulator of G-protein signaling 9-binding protein
FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to the photoreceptor outer segment, where phototransduction takes place. Enhances the ability of RGS9-1 to stimulate G protein GTPase activity, allowing the visual signal to be terminated on the physiologically time scale. It also controls the proteolytic stability of RGS9-1, probably by protecting it from degradation (By similarity).

SUBUNIT: Specifically interacts with isoform RGS9-1 of RGS9. Component of the RGS9-1-Gbeta5 complex composed of RGS9-1, Gbeta5 (GNB5) and RGS9BP (By similarity).

DISEASE: Prolonged electroretinal response suppression (PERRS) OMIM: Characterized by difficulty adjusting to sudden changes in luminance levels mediated by cones. mutations affecting the gene represented in this entry.

UniProt features for R9BP_HUMAN » Regulator of G-protein signaling 9-binding protein
CHAIN 1 235 Regulator of G-protein signaling 9- binding protein.
REGION 153 200 SNARE-like (By similarity).
COILED 29 54 Potential.
COILED 144 169 Potential.
Amino Acid Sequence for R9BP_HUMAN » Regulator of G-protein signaling 9-binding protein
MAREECKALL DGLNKTTACY HHLVLTVGGS ADSQNLRQEL QKTRQKAQEL AVSTCARLTA VLRDRGLAAD ERAEFERLWV AFSGCLDLLE ADMRRALELG AAFPLHAPRR PLVRTGVAGA SSGVAARALS TRSLRLEAEG DFDVADLREL EREVLQVGEM IDNMEMKVNV PRWTVQARQA AGAELLSTVS AGPSSVVSLQ ERGGGCDPRK ALAAILFGAV LLAAVALAVC VAKLS