PYRD_ARATH » Dihydroorotate dehydrogenase (quinone), mitochondrial

PYRD_ARATH » Dihydroorotate dehydrogenase (quinone), mitochondrial
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Topology in Mitochondrial inner membrane
Topologyintermembrane space
mitochondrial matrix side
PYRD_ARATH » Dihydroorotate dehydrogenase (quinone), mitochondrial » DHOdehase; Dihydroorotate oxidase;
Hydrophobic Thickness 28.6 ± 2.2 Å
Tilt Angle 0 ± 6°
ΔGtransfer -11.0 kcal/mol
ΔGfold -5.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology In
TM Segments 51-69 (46-72)
Pathways

Pyrimidine metabolism (KEGG)

uridine-5'-phosphate biosynthesis (BioCyc)

PDB none
OPM 1d3h (HUMAN), 1f76 (ECOLI), 1uum (RAT), 3i65 (PLAF7), 4cq8 (PLAF7)
Complexes none
Interactions none
Domains

AA: 123-443, PDBID: 1UUM, Subunit B, Seq Identity:52%, Dihydroorotate dehydrogenase

UniProt annotation for PYRD_ARATH » Dihydroorotate dehydrogenase (quinone), mitochondrial
FUNCTION: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

CATALYTIC ACTIVITY: (S)-dihydroorotate + a quinone = orotate + a quinol.

UniProt features for PYRD_ARATH » Dihydroorotate dehydrogenase (quinone), mitochondrial
TRANSIT 1 32 Mitochondrion (Potential).
CHAIN 33 460 Dihydroorotate dehydrogenase (quinone), mitochondrial.
REGION 190 194 Substrate binding (By similarity).
REGION 274 279 Substrate binding (By similarity).
REGION 348 349 Substrate binding (By similarity).
ACT_SITE 277 277 Nucleophile (By similarity).
Amino Acid Sequence for PYRD_ARATH » Dihydroorotate dehydrogenase (quinone), mitochondrial
MAGRAATSSA KWAREFLFRR VSSNPLGATR NCSSVPGASS APKVPHFSKR GRILTGATIG LAIAGGAYVS TADEATFCGW LFNATKVVNP FFALLDAEFA HKLAVSAAAR GWVPREKRPD PAILGLEVWG RKFSNPIGLA AGFDKNAEAT EGLLGMGFGF VEVGSVTPVP QEGNPKPRIF RLSQEGAIIN RCGFNSEGIV VVAKRLGAQH GKRMLAETSA TSSSPSDDVK PGGKSGPGIL GVNLGKNKTS EDAAADYVQG VHNLSQYADY LVINVSSPNT AGLRMLQGRK QLKDLVKKVQ AARDEMQWGD EGPPPLLVKI APDLSRGELE DIAAVALALH LDGLIISNTT VSRPDAVSNN PVATETGGLS GKPLFALSTN MLRDMYTLTR GKIPLIGCGG VSSGEDAYKK IRAGATLVQL YTGFAYGGPA LIPQIKEELV KCLERDGFKS IHEAIGADHR