PXDC2_HUMAN » Plexin domain-containing protein 2

PXDC2_HUMAN » Plexin domain-containing protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PXDC2_HUMAN » Plexin domain-containing protein 2 » Tumor endothelial marker 7-related protein;
Hydrophobic Thickness 37.2 ± 0.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -49.7 kcal/mol
ΔGfold -27.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 451-479 (444-480)
Pathways none
PDB none
OPM none
Complexes none
Interactions

NICA, Complex: NICA:PXDC2, PubMed

NICA, Complex: PXDC2:PSN1:NICA, PubMed

Domains

AA: 327-372, PDBID: 3AL8, Subunit B, Seq Identity:29%, Plexin repeat

UniProt annotation for PXDC2_HUMAN » Plexin domain-containing protein 2
FUNCTION: May play a role in tumor angiogenesis.

SUBUNIT: Interacts with CTTN.

TISSUE SPECIFICITY: Expressed in the endothelial cells of the stroma but not in the endothelial cells of normal colonic tissue.

UniProt features for PXDC2_HUMAN » Plexin domain-containing protein 2
SIGNAL 1 30 Potential.
CHAIN 31 529 Plexin domain-containing protein 2.
DOMAIN 327 372 PSI.
Amino Acid Sequence for PXDC2_HUMAN » Plexin domain-containing protein 2
MARFPKADLA AAGVMLLCHF FTDQFQFADG KPGDQILDWQ YGVTQAFPHT EEEVEVDSHA YSHRWKRNLD FLKAVDTNRA SVGQDSPEPR SFTDLLLDDG QDNNTQIEED TDHNYYISRI YGPSDSASRD LWVNIDQMEK DKVKIHGILS NTHRQAARVN LSFDFPFYGH FLREITVATG GFIYTGEVVH RMLTATQYIA PLMANFDPSV SRNSTVRYFD NGTALVVQWD HVHLQDNYNL GSFTFQATLL MDGRIIFGYK EIPVLVTQIS STNHPVKVGL SDAFVVVHRI QQIPNVRRRT IYEYHRVELQ MSKITNISAV EMTPLPTCLQ FNRCGPCVSS QIGFNCSWCS KLQRCSSGFD RHRQDWVDSG CPEESKEKMC ENTEPVETSS RTTTTVGATT TQFRVLTTTR RAVTSQFPTS LPTEDDTKIA LHLKDNGAST DDSAAEKKGG TLHAGLIIGI LILVLIVATA ILVTVYMYHH PTSAASIFFI ERRPSRWPAM KFRRGSGHPA YAEVEPVGEK EGFIVSEQC