PX11B_HUMAN » Peroxisomal membrane protein 11B

PX11B_HUMAN » Peroxisomal membrane protein 11B
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Topology in Peroxisome membrane
Topologyperoxisome lumenal side
cytoplasmic side
PX11B_HUMAN » Peroxisomal membrane protein 11B » Peroxin-11B;Peroxisomal biogenesis factor 11B;Protein PEX11 homolog beta;PEX11-beta;
Hydrophobic Thickness 31.6 ± 3.3 Å
Tilt Angle 22 ± 0°
ΔGtransfer -15.6 kcal/mol
ΔGfold -7.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 234-255 (234-258)
Pathways

Peroxisome (KEGG)

PDB none
OPM none
Complexes none
Interactions

FIS1, Complex: FIS1:PX11B, PubMed

PX11C, Complex: PX11B:PX11C

Domains

AA: 1-251, Peroxisomal biogenesis factor 11 (PEX11)

UniProt annotation for PX11B_HUMAN » Peroxisomal membrane protein 11B
FUNCTION: Involved in peroxisomal proliferation. May regulate peroxisomes division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane.

SUBUNIT: Interacts with PEX19.

DISEASE: Peroxisome biogenesis disorder 14B (PBD14B) OMIM: An autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed. mutations affecting the gene represented in this entry.

UniProt features for PX11B_HUMAN » Peroxisomal membrane protein 11B
CHAIN 1 259 Peroxisomal membrane protein 11B.
REGION 211 259 Interaction with PEX19 and peroxisome targeting.
Amino Acid Sequence for PX11B_HUMAN » Peroxisomal membrane protein 11B
MDAWVRFSAQ SQARERLCRA AQYACSLLGH ALQRHGASPE LQKQIRQLES HLSLGRKLLR LGNSADALES AKRAVHLSDV VLRFCITVSH LNRALYFACD NVLWAGKSGL APRVDQEKWA QRSFRYYLFS LIMNLSRDAY EIRLLMEQES SACSRRLKGS GGGVPGGSET GGLGGPGTPG GGLPQLALKL RLQVLLLARV LRGHPPLLLD VVRNACDLFI PLDKLGLWRC GPGIVGLCGL VSSILSILTL IYPWLRLKP