PVR_HUMAN » Poliovirus receptor

PVR_HUMAN » Poliovirus receptor
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PVR_HUMAN » Poliovirus receptor » Nectin-like protein 5;NECL-5;
Hydrophobic Thickness 37.6 ± 2.2 Å
Tilt Angle 1 ± 0°
ΔGtransfer -30.5 kcal/mol
ΔGfold -25.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 343-367 (342-370)
Pathways

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

Immune System (Reactome)

PDB 3j8f (1-417), 3j9f (28-143,8=142-243,9=242-333), 1dgi (28-329), 1nn8 (28-329), 4fqp (28-334), 3udw (C/D=28-145), 3uro (R=29-243), 3epd (R=30-242), 3epf (R=30-242), 3epc (R=30-242)
OPM none
Complexes

TIGIT:PVR_HUMAN

Interactions

CADH1, Complex: PVR:CADH1, PubMed

CD226, Complex: PVR:CD226, PubMed

PVRL1, Complex: PVR:PVRL1, PubMed

PVRL3, Complex: PVRL3:PVR, PubMed

TACT, Complex: TACT:PVR, PubMed

TIGIT, Complex: TIGIT:PVR, PDBID: 3UDW

TNR12, Complex: PVR:TNR12

Domains

AA: 32-142, PDBID: 3EPC, Subunit R, Seq Identity:100%, Immunoglobulin V-set domain

AA: 147-232, PDBID: 3EPC, Subunit R, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

UniProt annotation for PVR_HUMAN » Poliovirus receptor
FUNCTION: Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

SUBUNIT: Can form trans-heterodimers with PVRL3/nectin-3. The extracellular domain interacts with VTN, CD226 and CD96. The cytoplasmic domain interacts with DYNLT1. Interacts with HHV-5 UL141. Interacts with poliovirus capsid composed of VP1, VP2 and VP3, mainly through VP3. Binds with high affinity to TIGIT.

INDUCTION: Transcriptionally regulated by SHH.

DOMAIN: Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

MISCELLANEOUS: The V-type domain is necessary and sufficient for virus binding and uptake.

UniProt features for PVR_HUMAN » Poliovirus receptor
SIGNAL 1 20 Potential.
CHAIN 21 417 Poliovirus receptor.
DOMAIN 24 139 Ig-like V-type.
DOMAIN 145 237 Ig-like C2-type 1.
DOMAIN 244 328 Ig-like C2-type 2.
REGION 368 372 DYNLT1 binding.
DISULFID 49 123 By similarity.
DISULFID 166 221 By similarity.
DISULFID 266 312 By similarity.
Amino Acid Sequence for PVR_HUMAN » Poliovirus receptor
MARAMAAAWP LLLVALLVLS WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGI SRNAIIFLVL GILVFLILLG IGIYFYWSKC SREVLWHCHL CPSSTEHASA SANGHVSYSA VSRENSSSQD PQTEGTR