PVRL4_HUMAN » Poliovirus receptor-related protein 4

PVRL4_HUMAN » Poliovirus receptor-related protein 4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PVRL4_HUMAN » Poliovirus receptor-related protein 4 » Ig superfamily receptor LNIR;Nectin-4;
Hydrophobic Thickness 38.8 ± 1.6 Å
Tilt Angle 0 ± 0°
ΔGtransfer -53.7 kcal/mol
ΔGfold -28.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 345-372 (345-378)
Pathways

Adherens junction (KEGG)

Cell-Cell communication (Reactome)

PDB 4frw (A/B...=32-243), 4jjh (A/B=32-153), 4gjt (B/C=32-146)
OPM none
Complexes

PVRL4:PVRL4_HUMAN

Interactions

PVRL1, Complex: PVRL1:PVRL4, PubMed

PVRL2, Complex: PVRL2:PVRL4

PVRL4, Complex: Homodimer of poliovirus receptor-related protein 4, PDBID: 4FRW

TIGIT, Complex: PVRL4:TIGIT

Domains

AA: 35-146, PDBID: 4FRW, Subunit B, Seq Identity:100%, Immunoglobulin V-set domain

AA: 151-234, PDBID: 4FRW, Subunit B, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

AA: 256-319, PDBID: 3ALP, Subunit A, Seq Identity:42%, Immunoglobulin domain

UniProt annotation for PVRL4_HUMAN » Poliovirus receptor-related protein 4
FUNCTION: Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with PVRL2/nectin-1. Does not act as receptor for alpha-herpesvirus entry into cells.

SUBUNIT: Self-associates. Interacts via its Ig-like V-type domain with PVRL1/nectin-1 Ig-like V-type domain. Interacts via its C- terminus with MLLT4. Binds to Measles virus protein H and acts as a receptor for this virus.

TISSUE SPECIFICITY: Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma.

DISEASE: Ectodermal dysplasia-syndactyly syndrome 1 (EDSS1) OMIM: A form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDSS1 is characterized by the association of hair and teeth abnormalities with cutaneous syndactyly of the hands and/or feet. Hair morphologic abnormalities include twists at irregular intervals (pilli torti) and swelling along the shafts, particularly associated with areas of breakage. Dental findings consist of abnormally widely spaced teeth, with peg- shaped and conical crowns. Patients have normal sweating. mutations affecting the gene represented in this entry.

UniProt features for PVRL4_HUMAN » Poliovirus receptor-related protein 4
SIGNAL 1 31 Potential.
CHAIN 32 510 Poliovirus receptor-related protein 4.
CHAIN 32 ? Processed poliovirus receptor-related protein 4.
DOMAIN 32 144 Ig-like V-type 1.
DOMAIN 148 237 Ig-like C2-type 1.
DOMAIN 248 331 Ig-like C2-type 2.
DISULFID 171 223 By similarity.
DISULFID 270 315 By similarity.
Amino Acid Sequence for PVRL4_HUMAN » Poliovirus receptor-related protein 4
MPLSLGAEMW GPEAWLLLLL LLASFTGRCP AGELETSDVV TVVLGQDAKL PCFYRGDSGE QVGQVAWARV DAGEGAQELA LLHSKYGLHV SPAYEGRVEQ PPPPRNPLDG SVLLRNAVQA DEGEYECRVS TFPAGSFQAR LRLRVLVPPL PSLNPGPALE EGQGLTLAAS CTAEGSPAPS VTWDTEVKGT TSSRSFKHSR SAAVTSEFHL VPSRSMNGQP LTCVVSHPGL LQDQRITHIL HVSFLAEASV RGLEDQNLWH IGREGAMLKC LSEGQPPPSY NWTRLDGPLP SGVRVDGDTL GFPPLTTEHS GIYVCHVSNE FSSRDSQVTV DVLDPQEDSG KQVDLVSASV VVVGVIAALL FCLLVVVVVL MSRYHRRKAQ QMTQKYEEEL TLTRENSIRR LHSHHTDPRS QPEESVGLRA EGHPDSLKDN SSCSVMSEEP EGRSYSTLTT VREIETQTEL LSPGSGRAEE EEDQDEGIKQ AMNHFVQENG TLRAKPTGNG IYINGRGHLV