PVRL3_HUMAN » Poliovirus receptor-related protein 3

PVRL3_HUMAN » Poliovirus receptor-related protein 3
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PVRL3_HUMAN » Poliovirus receptor-related protein 3 » CDw113;Nectin-3;
Hydrophobic Thickness 38.0 ± 1.4 Å
Tilt Angle 2 ± 1°
ΔGtransfer -49.2 kcal/mol
ΔGfold -22.9 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 402-429 (400-432)
Pathways

Adherens junction (KEGG)

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

PDB 4fom (A=58-359)
OPM none
Complexes none
Interactions

PVRL1, Complex: PVRL1:PVRL3, PubMed

PVRL2, Complex: PVRL2:PVRL3, PubMed

PVR, Complex: PVRL3:PVR, PubMed

TIGIT, Complex: PVRL3:TIGIT

Domains

AA: 61-167, PDBID: 4FOM, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 173-257, PDBID: 4FOM, Subunit A, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

UniProt annotation for PVRL3_HUMAN » Poliovirus receptor-related protein 3
FUNCTION: Plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1. Also involved in the formation of cell-cell junctions, including adherens junctions and synapses. Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation. Plays a role in the morphology of the ciliary body.

SUBUNIT: Cis- and trans-homodimer. Can form trans-heterodimers with PVRL1/nectin-1, PVRL2/nectin-2, PVR, IGSF4B/Necl-1 and with IGSF4. Interaction between PVRL1 and PVRL3 on the pre- and postsynaptic sites, respectively, initiates the formation of puncta adherentia junctions between axons and dendrites. Interacts (via Cytoplasmic domain) with MLLT4/afadin, providing a connection with the actin cytoskeleton. Binds with low affinity to TIGIT.

TISSUE SPECIFICITY: Predominantly expressed in testis and placenta as well as in many cell lines, including epithelial cell lines.

UniProt features for PVRL3_HUMAN » Poliovirus receptor-related protein 3
SIGNAL 1 57 Potential.
CHAIN 58 549 Poliovirus receptor-related protein 3.
DOMAIN 59 165 Ig-like V-type.
DOMAIN 170 258 Ig-like C2-type 1.
DOMAIN 269 354 Ig-like C2-type 2.
DISULFID 78 148 By similarity.
DISULFID 193 246 By similarity.
DISULFID 291 338 By similarity.
Amino Acid Sequence for PVRL3_HUMAN » Poliovirus receptor-related protein 3
MARTLRPSPL CPGGGKAQLS SASLLGAGLL LQPPTPPPLL LLLFPLLLFS RLCGALAGPI IVEPHVTAVW GKNVSLKCLI EVNETITQIS WEKIHGKSSQ TVAVHHPQYG FSVQGEYQGR VLFKNYSLND ATITLHNIGF SDSGKYICKA VTFPLGNAQS STTVTVLVEP TVSLIKGPDS LIDGGNETVA AICIAATGKP VAHIDWEGDL GEMESTTTSF PNETATIISQ YKLFPTRFAR GRRITCVVKH PALEKDIRYS FILDIQYAPE VSVTGYDGNW FVGRKGVNLK CNADANPPPF KSVWSRLDGQ WPDGLLASDN TLHFVHPLTF NYSGVYICKV TNSLGQRSDQ KVIYISDPPT TTTLQPTIQW HPSTADIEDL ATEPKKLPFP LSTLATIKDD TIATIIASVV GGALFIVLVS VLAGIFCYRR RRTFRGDYFA KNYIPPSDMQ KESQIDVLQQ DELDSYPDSV KKENKNPVNN LIRKDYLEEP EKTQWNNVEN LNRFERPMDY YEDLKMGMKF VSDEHYDENE DDLVSHVDGS VISRREWYV