PVRL2_HUMAN » Poliovirus receptor-related protein 2

PVRL2_HUMAN » Poliovirus receptor-related protein 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PVRL2_HUMAN » Poliovirus receptor-related protein 2 » Herpes virus entry mediator B;Herpesvirus entry mediator B; HveB; Nectin-2;
Hydrophobic Thickness 26.0 ± 2.0 Å
Tilt Angle 0 ± 0°
ΔGtransfer -21.9 kcal/mol
ΔGfold -15.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 361-385 (361-386)
Pathways

Adherens junction (KEGG)

Cell adhesion molecules (KEGG)

Cell-Cell communication (Reactome)

Herpes simplex infection (KEGG)

Immune System (Reactome)

PDB 4dfi (32-158), 4dfh (A/B=32-158), 4hza (A/B=32-158), 3r0n (A=32-158)
OPM none
Complexes

PVRL2:PVRL2_HUMAN

Interactions

ATPK, Complex: ATPK:PVRL2, PubMed

CD226, Complex: PVRL2:CD226, PubMed

PVRL2, Complex: Homodimer of poliovirus receptor-related protein 2, PDBID: 4HZA

PVRL3, Complex: PVRL2:PVRL3, PubMed

PVRL4, Complex: PVRL2:PVRL4

TIGIT, Complex: PVRL2:TIGIT

TNR12, Complex: PVRL2:TNR12

Domains

AA: 37-159, PDBID: 3R0N, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 159-249, PDBID: 4FMK, Subunit A, Seq Identity:57%, CD80-like C2-set immunoglobulin domain

UniProt annotation for PVRL2_HUMAN » Poliovirus receptor-related protein 2
FUNCTION: Probable cell adhesion protein.

SUBUNIT: Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.

TISSUE SPECIFICITY: Ubiquitous.

UniProt features for PVRL2_HUMAN » Poliovirus receptor-related protein 2
SIGNAL 1 31 Potential.
CHAIN 32 538 Poliovirus receptor-related protein 2.
DOMAIN 32 156 Ig-like V-type.
DOMAIN 162 256 Ig-like C2-type 1.
DOMAIN 261 345 Ig-like C2-type 2.
DISULFID 54 140 By similarity.
DISULFID 183 238 By similarity.
DISULFID 283 329 By similarity.
Amino Acid Sequence for PVRL2_HUMAN » Poliovirus receptor-related protein 2
MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV ELPCHLLPPV PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP NTAGAGATGG IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL EGPPSYKPPT PKAKLEAQEM PSQLFTLGAS EHSPLKTPYF DAGASCTEQE MPRYHELPTL EERSGPLHPG ATSLGSPIPV PPGPPAVEDV SLDLEDEEGE EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV