PTPRU_HUMAN » Receptor-type tyrosine-protein phosphatase U

PTPRU_HUMAN » Receptor-type tyrosine-protein phosphatase U
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRU_HUMAN » Receptor-type tyrosine-protein phosphatase U » R-PTP-U; Pancreatic carcinoma phosphatase 2;PCP-2; Protein-tyrosine phosphatase J;PTP-J; hPTP-J; Protein-tyrosine phosphatase pi;PTP pi; Protein-tyrosine phosphatase receptor omicron;PTP-RO; Receptor-type protein-tyrosine phosphatase psi;R-PTP-psi;
Hydrophobic Thickness 33.2 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -48.5 kcal/mol
ΔGfold -22.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 745-773 (737-774)
Pathways

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

CADH2, Complex: PTPRU:CADH2, PubMed

ERBB2, Complex: ERBB2:PTPRU, PubMed

KIT, Complex: KIT:PTPRU, PubMed

TIE2, Complex: PTPRU:TIE2, PubMed

Domains

AA: 27-187, PDBID: 2C9A, Subunit A, Seq Identity:47%, MAM domain, meprin/A5/mu

AA: 287-370, PDBID: 2V5Y, Subunit A, Seq Identity:64%, Fibronectin type III domain

AA: 490-579, PDBID: 2V5Y, Subunit A, Seq Identity:44%, Fibronectin type III domain

AA: 913-1143, PDBID: 2OOQ, Subunit A, Seq Identity:59%, Protein-tyrosine phosphatase

AA: 1203-1438, PDBID: 2I1Y, Subunit A, Seq Identity:40%, Protein-tyrosine phosphatase

UniProt annotation for PTPRU_HUMAN » Receptor-type tyrosine-protein phosphatase U
FUNCTION: Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

SUBUNIT: Forms homooligomeric complexes which mediate cell homotypic adhesion (Probable). Interacts (via the cytoplasmic juxtamembrane domain) with CTNNB1; may mediate interaction with the cadherin/catenin adhesion complex. Interacts with KIT. May interact with AP3B1.

TISSUE SPECIFICITY: High levels in brain, pancreas, and skeletal muscle; less in colon, kidney, liver, stomach, and uterus; not expressed in placenta and spleen. Also detected in heart, prostate, lung, thymus, testis and ovary. Ubiquitously expressed in brain. Expressed by hematopoietic stem cells.

DEVELOPMENTAL STAGE: Expressed in fetal brain, lung and kidney.

INDUCTION: Up-regulated upon cell contact (at protein level). Down-regulated by phorbol ester (at protein level) and calcium ionophore but up-regulated by phorbol ester in megakaryocytic cells (PubMed).

UniProt features for PTPRU_HUMAN » Receptor-type tyrosine-protein phosphatase U
SIGNAL 1 18 Potential.
CHAIN 19 1446 Receptor-type tyrosine-protein phosphatase U.
DOMAIN 25 188 MAM.
DOMAIN 190 275 Ig-like C2-type.
DOMAIN 285 377 Fibronectin type-III 1.
DOMAIN 383 481 Fibronectin type-III 2.
DOMAIN 482 585 Fibronectin type-III 3.
DOMAIN 592 674 Fibronectin type-III 4.
DOMAIN 888 1144 Tyrosine-protein phosphatase 1.
DOMAIN 1176 1439 Tyrosine-protein phosphatase 2.
REGION 771 887 Mediates interaction with CTNNB1 (By similarity).
REGION 1085 1091 Substrate binding (By similarity).
ACT_SITE 1085 1085 Phosphocysteine intermediate (By similarity).
ACT_SITE 1380 1380 Phosphocysteine intermediate (By similarity).
DISULFID 210 264 Potential.
Amino Acid Sequence for PTPRU_HUMAN » Receptor-type tyrosine-protein phosphatase U
MARAQALVLA LTFQLCAPET ETPAAGCTFE EASDPAVPCE YSQAQYDDFQ WEQVRIHPGT RAPADLPHGS YLMVNTSQHA PGQRAHVIFQ SLSENDTHCV QFSYFLYSRD GHSPGTLGVY VRVNGGPLGS AVWNMTGSHG RQWHQAELAV STFWPNEYQV LFEALISPDR RGYMGLDDIL LLSYPCAKAP HFSRLGDVEV NAGQNASFQC MAAGRAAEAE RFLLQRQSGA LVPAAGVRHI SHRRFLATFP LAAVSRAEQD LYRCVSQAPR GAGVSNFAEL IVKEPPTPIA PPQLLRAGPT YLIIQLNTNS IIGDGPIVRK EIEYRMARGP WAEVHAVSLQ TYKLWHLDPD TEYEISVLLT RPGDGGTGRP GPPLISRTKC AEPMRAPKGL AFAEIQARQL TLQWEPLGYN VTRCHTYTVS LCYHYTLGSS HNQTIRECVK TEQGVSRYTI KNLLPYRNVH VRLVLTNPEG RKEGKEVTFQ TDEDVPSGIA AESLTFTPLE DMIFLKWEEP QEPNGLITQY EISYQSIESS DPAVNVPGPR RTISKLRNET YHVFSNLHPG TTYLFSVRAR TGKGFGQAAL TEITTNISAP SFDYADMPSP LGESENTITV LLRPAQGRGA PISVYQVIVE EERARRLRRE PGGQDCFPVP LTFEAALARG LVHYFGAELA ASSLPEAMPF TVGDNQTYRG FWNPPLEPRK AYLIYFQAAS HLKGETRLNC IRIARKAACK ESKRPLEVSQ RSEEMGLILG ICAGGLAVLI LLLGAIIVII RKGRDHYAYS YYPKPVNMTK ATVNYRQEKT HMMSAVDRSF TDQSTLQEDE RLGLSFMDTH GYSTRGDQRS GGVTEASSLL GGSPRRPCGR KGSPYHTGQL HPAVRVADLL QHINQMKTAE GYGFKQEYES FFEGWDATKK KDKVKGSRQE PMPAYDRHRV KLHPMLGDPN ADYINANYID GYHRSNHFIA TQGPKPEMVY DFWRMVWQEH CSSIVMITKL VEVGRVKCSR YWPEDSDTYG DIKIMLVKTE TLAEYVVRTF ALERRGYSAR HEVRQFHFTA WPEHGVPYHA TGLLAFIRRV KASTPPDAGP IVIHCSAGTG RTGCYIVLDV MLDMAECEGV VDIYNCVKTL CSRRVNMIQT EEQYIFIHDA ILEACLCGET TIPVSEFKAT YKEMIRIDPQ SNSSQLREEF QTLNSVTPPL DVEECSIALL PRNRDKNRSM DVLPPDRCLP FLISTDGDSN NYINAALTDS YTRSAAFIVT LHPLQSTTPD FWRLVYDYGC TSIVMLNQLN QSNSAWPCLQ YWPEPGRQQY GLMEVEFMSG TADEDLVARV FRVQNISRLQ EGHLLVRHFQ FLRWSAYRDT PDSKKAFLHL LAEVDKWQAE SGDGRTIVHC LNGGGRSGTF CACATVLEMI RCHNLVDVFF AAKTLRNYKP NMVETMDQYH FCYDVALEYL EGLESR