PTPRT_HUMAN » Receptor-type tyrosine-protein phosphatase T

PTPRT_HUMAN » Receptor-type tyrosine-protein phosphatase T
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRT_HUMAN » Receptor-type tyrosine-protein phosphatase T » R-PTP-T; Receptor-type tyrosine-protein phosphatase rho;RPTP-rho;
Hydrophobic Thickness 30.0 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -43.8 kcal/mol
ΔGfold -23.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 764-788 (762-791)
Pathways none
PDB 2ooq (868-1151)
OPM none
Complexes none
Interactions

PTPRN, Complex: PTPRT:PTPRN, PubMed

Domains

AA: 32-190, PDBID: 2C9A, Subunit A, Seq Identity:65%, MAM domain, meprin/A5/mu

AA: 290-374, PDBID: 2V5Y, Subunit A, Seq Identity:59%, Fibronectin type III domain

AA: 498-578, PDBID: 2V5Y, Subunit A, Seq Identity:60%, Fibronectin type III domain

AA: 912-1142, PDBID: 2OOQ, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

AA: 1202-1436, PDBID: 2PA5, Subunit A, Seq Identity:39%, Protein-tyrosine phosphatase

UniProt annotation for PTPRT_HUMAN » Receptor-type tyrosine-protein phosphatase T
FUNCTION: May be involved in both signal transduction and cellular adhesion in the CNS.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

TISSUE SPECIFICITY: Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes.

UniProt features for PTPRT_HUMAN » Receptor-type tyrosine-protein phosphatase T
SIGNAL 1 25 Potential.
CHAIN 26 1441 Receptor-type tyrosine-protein phosphatase T.
DOMAIN 30 191 MAM.
DOMAIN 193 284 Ig-like C2-type.
DOMAIN 288 379 Fibronectin type-III 1.
DOMAIN 386 480 Fibronectin type-III 2.
DOMAIN 481 584 Fibronectin type-III 3.
DOMAIN 589 726 Fibronectin type-III 4.
DOMAIN 889 1143 Tyrosine-protein phosphatase 1.
DOMAIN 1175 1437 Tyrosine-protein phosphatase 2.
REGION 1084 1090 Substrate binding (By similarity).
ACT_SITE 1084 1084 Phosphocysteine intermediate (By similarity).
ACT_SITE 1378 1378 Phosphocysteine intermediate (By similarity).
DISULFID 213 267 By similarity.
Amino Acid Sequence for PTPRT_HUMAN » Receptor-type tyrosine-protein phosphatase T
MASLAALALS LLLRLQLPPL PGARAQSAAG GCSFDEHYSN CGYSVALGTN GFTWEQINTW EKPMLDQAVP TGSFMMVNSS GRASGQKAHL LLPTLKENDT HCIDFHYYFS SRDRSSPGAL NVYVKVNGGP QGNPVWNVSG VVTEGWVKAE LAISTFWPHF YQVIFESVSL KGHPGYIAVD EVRVLAHPCR KAPHFLRLQN VEVNVGQNAT FQCIAGGKWS QHDKLWLQQW NGRDTALMVT RVVNHRRFSA TVSVADTAQR SVSKYRCVIR SDGGSGVSNY AELIVKEPPT PIAPPELLAV GATYLWIKPN ANSIIGDGPI ILKEVEYRTT TGTWAETHIV DSPNYKLWHL DPDVEYEIRV LLTRPGEGGT GPPGPPLTTR TKCADPVHGP QNVEIVDIRA RQLTLQWEPF GYAVTRCHSY NLTVQYQYVF NQQQYEAEEV IQTSSHYTLR GLRPFMTIRL RLLLSNPEGR MESEELVVQT EEDVPGAVPL ESIQGGPFEE KIYIQWKPPN ETNGVITLYE INYKAVGSLD PSADLSSQRG KVFKLRNETH HLFVGLYPGT TYSFTIKAST AKGFGPPVTT RIATKISAPS MPEYDTDTPL NETDTTITVM LKPAQSRGAP VSVYQLVVKE ERLQKSRRAA DIIECFSVPV SYRNASSLDS LHYFAAELKP ANLPVTQPFT VGDNKTYNGY WNPPLSPLKS YSIYFQALSK ANGETKINCV RLATKAPMGS AQVTPGTPLC LLTTGASTQN SNTVEPEKQV DNTVKMAGVI AGLLMFIIIL LGVMLTIKRR RNAYSYSYYL SQRKLAKKQK ETQSGAQREM GPVASADKPT TKLSASRNDE GFSSSSQDVN GFTDGSRGEL SQPTLTIQTH PYRTCDPVEM SYPRDQFQPA IRVADLLQHI TQMKRGQGYG FKEEYEALPE GQTASWDTAK EDENRNKNRY GNIISYDHSR VRLLVLDGDP HSDYINANYI DGYHRPRHYI ATQGPMQETV KDFWRMIWQE NSASIVMVTN LVEVGRVKCV RYWPDDTEVY GDIKVTLIET EPLAEYVIRT FTVQKKGYHE IRELRLFHFT SWPDHGVPCY ATGLLGFVRQ VKFLNPPEAG PIVVHCSAGA GRTGCFIAID TMLDMAENEG VVDIFNCVRE LRAQRVNLVQ TEEQYVFVHD AILEACLCGN TAIPVCEFRS LYYNISRLDP QTNSSQIKDE FQTLNIVTPR VRPEDCSIGL LPRNHDKNRS MDVLPLDRCL PFLISVDGES SNYINAALMD SHKQPAAFVV TQHPLPNTVA DFWRLVFDYN CSSVVMLNEM DTAQFCMQYW PEKTSGCYGP IQVEFVSADI DEDIIHRIFR ICNMARPQDG YRIVQHLQYI GWPAYRDTPP SKRSLLKVVR RLEKWQEQYD GREGRTVVHC LNGGGRSGTF CAICSVCEMI QQQNIIDVFH IVKTLRNNKS NMVETLEQYK FVYEVALEYL SSF