PTPRS_HUMAN » Receptor-type tyrosine-protein phosphatase S

PTPRS_HUMAN » Receptor-type tyrosine-protein phosphatase S
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRS_HUMAN » Receptor-type tyrosine-protein phosphatase S » R-PTP-S; Receptor-type tyrosine-protein phosphatase sigma;R-PTP-sigma;
Hydrophobic Thickness 33.6 ± 0.8 Å
Tilt Angle 7 ± 4°
ΔGtransfer -51.8 kcal/mol
ΔGfold -24.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 1282-1307 (1280-1309)
Pathways none
PDB 2fh7 (1365-1948), 4bpc (1367-1948), 2yd3 (30-235), 2yd2 (30-244), 4pbx (30-614), 2yd9 (A=30-334)
OPM none
Complexes none
Interactions

EGFR, Complex: EGFR:PTPRS, PubMed

PTPRA, Complex: PTPRS:PTPRA, PubMed

PTPRD, Complex: PTPRS:PTPRD, PubMed

PTPRE, Complex: PTPRS:PTPRE, PubMed

PTPRM, Complex: PTPRS:PTPRM, PubMed

PTPRN, Complex: PTPRN:PTPRS, PubMed

RYK, Complex: PTPRS:RYK, PubMed

Domains

AA: 33-124, PDBID: 2YD2, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 135-220, PDBID: 2YD2, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 245-328, PDBID: 2YD9, Subunit A, Seq Identity:100%, Immunoglobulin I-set domain

AA: 333-414, PDBID: 4PBX, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 428-513, PDBID: 4PBX, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 526-606, PDBID: 4PBX, Subunit A, Seq Identity:100%, Fibronectin type III domain

AA: 620-708, PDBID: 2EDX, Subunit A, Seq Identity:51%, Fibronectin type III domain

AA: 722-821, PDBID: 2DLH, Subunit A, Seq Identity:30%, Fibronectin type III domain

AA: 835-917, PDBID: 2ED8, Subunit A, Seq Identity:31%, Fibronectin type III domain

AA: 930-1022, PDBID: 2EDY, Subunit A, Seq Identity:43%, Fibronectin type III domain

AA: 1416-1647, PDBID: 2FH7, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

AA: 1705-1938, PDBID: 2FH7, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTPRS_HUMAN » Receptor-type tyrosine-protein phosphatase S
FUNCTION: Interacts with LAR-interacting protein LIP.1.

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

SUBUNIT: Interacts with PPFIA1, PPFIA2 and PPFIA3.

TISSUE SPECIFICITY: Detected in all tissues tested except for placenta and liver.

UniProt features for PTPRS_HUMAN » Receptor-type tyrosine-protein phosphatase S
SIGNAL 1 29 Potential.
CHAIN 30 1948 Receptor-type tyrosine-protein phosphatase S.
DOMAIN 33 123 Ig-like C2-type 1.
DOMAIN 135 233 Ig-like C2-type 2.
DOMAIN 245 327 Ig-like C2-type 3.
DOMAIN 332 420 Fibronectin type-III 1.
DOMAIN 426 520 Fibronectin type-III 2.
DOMAIN 525 614 Fibronectin type-III 3.
DOMAIN 618 715 Fibronectin type-III 4.
DOMAIN 720 828 Fibronectin type-III 5.
DOMAIN 836 923 Fibronectin type-III 6.
DOMAIN 928 1031 Fibronectin type-III 7.
DOMAIN 1033 1117 Fibronectin type-III 8.
DOMAIN 1393 1648 Tyrosine-protein phosphatase 1.
DOMAIN 1680 1939 Tyrosine-protein phosphatase 2.
REGION 1589 1595 Substrate binding (By similarity).
ACT_SITE 1589 1589 Phosphocysteine intermediate (By similarity).
ACT_SITE 1880 1880 Phosphocysteine intermediate (By similarity).
SITE 1197 1198 Cleavage (By similarity).
DISULFID 54 107 Potential.
DISULFID 156 216 Potential.
DISULFID 266 311 Potential.
Amino Acid Sequence for PTPRS_HUMAN » Receptor-type tyrosine-protein phosphatase S
MAPTWGPGMV SVVGPMGLLV VLLVGGCAAE EPPRFIKEPK DQIGVSGGVA SFVCQATGDP KPRVTWNKKG KKVNSQRFET IEFDESAGAV LRIQPLRTPR DENVYECVAQ NSVGEITVHA KLTVLREDQL PSGFPNIDMG PQLKVVERTR TATMLCAASG NPDPEITWFK DFLPVDPSAS NGRIKQLRSE TFESTPIRGA LQIESSEETD QGKYECVATN SAGVRYSSPA NLYVRELREV RRVAPRFSIL PMSHEIMPGG NVNITCVAVG SPMPYVKWMQ GAEDLTPEDD MPVGRNVLEL TDVKDSANYT CVAMSSLGVI EAVAQITVKS LPKAPGTPMV TENTATSITI TWDSGNPDPV SYYVIEYKSK SQDGPYQIKE DITTTRYSIG GLSPNSEYEI WVSAVNSIGQ GPPSESVVTR TGEQAPASAP RNVQARMLSA TTMIVQWEEP VEPNGLIRGY RVYYTMEPEH PVGNWQKHNV DDSLLTTVGS LLEDETYTVR VLAFTSVGDG PLSDPIQVKT QQGVPGQPMN LRAEARSETS ITLSWSPPRQ ESIIKYELLF REGDHGREVG RTFDPTTSYV VEDLKPNTEY AFRLAARSPQ GLGAFTPVVR QRTLQSKPSA PPQDVKCVSV RSTAILVSWR PPPPETHNGA LVGYSVRYRP LGSEDPEPKE VNGIPPTTTQ ILLEALEKWT QYRITTVAHT EVGPGPESSP VVVRTDEDVP SAPPRKVEAE ALNATAIRVL WRSPAPGRQH GQIRGYQVHY VRMEGAEARG PPRIKDVMLA DAQWETDDTA EYEMVITNLQ PETAYSITVA AYTMKGDGAR SKPKVVVTKG AVLGRPTLSV QQTPEGSLLA RWEPPAGTAE DQVLGYRLQF GREDSTPLAT LEFPPSEDRY TASGVHKGAT YVFRLAARSR GGLGEEAAEV LSIPEDTPRG HPQILEAAGN ASAGTVLLRW LPPVPAERNG AIVKYTVAVR EAGALGPARE TELPAAAEPG AENALTLQGL KPDTAYDLQV RAHTRRGPGP FSPPVRYRTF LRDQVSPKNF KVKMIMKTSV LLSWEFPDNY NSPTPYKIQY NGLTLDVDGR TTKKLITHLK PHTFYNFVLT NRGSSLGGLQ QTVTAWTAFN LLNGKPSVAP KPDADGFIMV YLPDGQSPVP VQSYFIVMVP LRKSRGGQFL TPLGSPEDMD LEELIQDISR LQRRSLRHSR QLEVPRPYIA ARFSVLPPTF HPGDQKQYGG FDNRGLEPGH RYVLFVLAVL QKSEPTFAAS PFSDPFQLDN PDPQPIVDGE EGLIWVIGPV LAVVFIICIV IAILLYKNKP DSKRKDSEPR TKCLLNNADL APHHPKDPVE MRRINFQTPD SGLRSPLREP GFHFESMLSH PPIPIADMAE HTERLKANDS LKLSQEYESI DPGQQFTWEH SNLEVNKPKN RYANVIAYDH SRVILQPIEG IMGSDYINAN YVDGYRRQNA YIATQGPLPE TFGDFWRMVW EQRSATIVMM TRLEEKSRIK CDQYWPNRGT ETYGFIQVTL LDTIELATFC VRTFSLHKNG SSEKREVRQF QFTAWPDHGV PEYPTPFLAF LRRVKTCNPP DAGPIVVHCS AGVGRTGCFI VIDAMLERIK PEKTVDVYGH VTLMRSQRNY MVQTEDQYSF IHEALLEAVG CGNTEVPARS LYAYIQKLAQ VEPGEHVTGM ELEFKRLANS KAHTSRFISA NLPCNKFKNR LVNIMPYEST RVCLQPIRGV EGSDYINASF IDGYRQQKAY IATQGPLAET TEDFWRMLWE NNSTIVVMLT KLREMGREKC HQYWPAERSA RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTVRQFQ FTDWPEQGVP KSGEGFIDFI GQVHKTKEQF GQDGPISVHC SAGVGRTGVF ITLSIVLERM RYEGVVDIFQ TVKMLRTQRP AMVQTEDEYQ FCYQAALEYL GSFDHYAT