PTPRR_HUMAN » Receptor-type tyrosine-protein phosphatase R

PTPRR_HUMAN » Receptor-type tyrosine-protein phosphatase R
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
PTPRR_HUMAN » Receptor-type tyrosine-protein phosphatase R » R-PTP-R; Ch-1PTPase;NC-PTPCOM1;Protein-tyrosine phosphatase PCPTP1;
Hydrophobic Thickness 30.8 ± 1.6 Å
Tilt Angle 0 ± 3°
ΔGtransfer -49.1 kcal/mol
ΔGfold -24.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 227-252 (224-252)
Pathways

MAPK signaling pathway (KEGG)

PDB 2a8b (375-655)
OPM none
Complexes none
Interactions

CADH2, Complex: CADH2:PTPRR

PGFRB, Complex: PGFRB:PTPRR

Domains

AA: 415-646, PDBID: 2A8B, Subunit A, Seq Identity:100%, Protein-tyrosine phosphatase

UniProt annotation for PTPRR_HUMAN » Receptor-type tyrosine-protein phosphatase R
FUNCTION: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

SUBUNIT: Interacts with MAPKs.

TISSUE SPECIFICITY: Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.

UniProt features for PTPRR_HUMAN » Receptor-type tyrosine-protein phosphatase R
SIGNAL 1 21 Potential.
CHAIN 22 657 Receptor-type tyrosine-protein phosphatase R.
DOMAIN 393 647 Tyrosine-protein phosphatase.
REGION 588 594 Substrate binding (By similarity).
ACT_SITE 588 588 Phosphocysteine intermediate (By similarity).
Amino Acid Sequence for PTPRR_HUMAN » Receptor-type tyrosine-protein phosphatase R
MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI EKSLDIAPQK IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD GQDLEVENLP IPAANVIVVT LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ VHINRLIGKK NSIELFVSPI NRKTGISDAL PSEEVLRSLN INVLHQSLSQ FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI IVTCLMILYR LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN VVVDPQGRGA PEIKATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL GNIEPFVSIP TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI PMNFVDPKEI DIPRHGTKNR YKTILPNPLS RVCLRPKNVT DSLSTYINAN YIRGYSGKEK AFIATQGPMI NTVDDFWQMV WQEDSPVIVM ITKLKEKNEK CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH TQHVKHYWYT SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR LSAETVQ